A crucial role of host CD80 and CD86 in rat cardiac xenograft rejection in mice

Transplantation
M KanoY Morishita

Abstract

Graft rejection can be initiated by two primary pathways of antigen presentation: (a) direct activation of host T cells by donor-derived antigen presenting cells (APC) and (b) indirect presentation of processed graft antigens by host APC. We investigated the differential roles for direct and indirect antigen presentation by preventing the CD28 costimulatory pathway with monoclonal antibodies to rat or mouse CD80 and CD86 in a rat-to-mouse cardiac transplantation model. Although the mouse anti-rat monoclonal antibodies to CD80 and CD86 did not significantly prolong the survival of rat cardiac xenografts in mice, the rat anti-mouse monoclonal antibodies to CD80 and CD86 did prolong the survival. Development of the anti-donor antibodies was inhibited, and the deposition of C3, IgM, and IgG on endothelium in the xenografts was mild in the anti-mouse CD80/CD86-treated mice. Infiltration of macrophages, neutrophils, and lymphocytes expressing perforin and interferon-gamma was decreased by the anti-mouse CD80/CD86 treatment. These findings suggest that the indirect antigen presentation, which is mediated by CD80 and CD86 pathway on host APC, plays a crucial role in concordant cardiac xenograft rejection.

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Citations

Sep 29, 2011·Tissue Engineering. Part a·Daniel J HueyKyriacos A Athanasiou
Jan 27, 2006·Transplantation·Karoline A HosiawaDavid J Kelvin
Nov 30, 2006·Transplantation·Hilton GockAnthony J F d'Apice
Dec 16, 1998·Xenotransplantation·M Koulmanda, H Auchincloss
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ingrid C RulifsonJeffrey A Bluestone
Apr 29, 2000·Current Opinion in Urology·K KishimotoM H Sayegh
Feb 1, 2011·American Journal of Reproductive Immunology : AJRI·Li-Ping JinDa-Jin Li
Apr 13, 2011·American Journal of Reproductive Immunology : AJRI·Li-Ping JinDa-Jin Li
Jun 12, 2003·Transplant Immunology·Michel P M VierboomMargreet Jonker
Feb 4, 2005·Journal of the American Society of Nephrology : JASN·Kai SingbartlHugo Van Aken
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karoline A HosiawaDavid J Kelvin
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li-Ping JinMin-Min Yuan

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