PMID: 8947907Nov 1, 1996Paper

A CT assisted method for absolute quantitation of internal radioactivity

Medical Physics
A LiuA A Raubitschek

Abstract

A method is described for the determination of radioactivity (microCi or MBq) at an organ site within an object or patient. Using both anatomic image data (CT or MRI scans) and planar gamma camera images, activity at depth is determined using a matrix inversion method based on least squares. The result of the inversion analysis was the unknown set of n linear (uniform) activity densities representative of each organ within the phantom or patient. The problem was overdetermined since the number of unknown activity densities (microCi/cm) was much less than the number of analysis points (N) within the nuclear image. This method, defined as the CT assisted matrix inversion (CAMI) technique, was accurate to within 15% for a three "organ" plastic phantom, wherein the organs were right circular cylinders having activities of 74 to 508 microCi (or 2.74 MBq to 18.8 MBq). This accuracy included image quantitation effects, particularly assumptions concerning attenuation correction. The average absolute percent error of the estimated activity in four distinct radioactive volumes in the phantom was 9.8%. It was found that the background activity within the phantom was estimated to be too high if sampling regions near strong sources were use...Continue Reading

Citations

Sep 9, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Yannick BerkerBernd Schweizer
Jun 25, 1998·Nuclear Medicine and Biology·A LiuA A Raubitschek
Nov 27, 2002·Academic Radiology·Bruce H HasegawaAnne E Sakdinawat
May 29, 2009·Medical Physics·Eleonora VanziFabio Di Martino
Apr 9, 2008·Seminars in Nuclear Medicine·Youngho SeoBruce H Hasegawa
Jun 5, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew M ScottLloyd J Old

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