A CT-based deep learning model for predicting the nuclear grade of clear cell renal cell carcinoma

European Journal of Radiology
Fan LinEnming Cui

Abstract

To investigate the effects of different methodologies on the performance of deep learning (DL) model for differentiating high- from low-grade clear cell renal cell carcinoma (ccRCC). Patients with pathologically proven ccRCC diagnosed between October 2009 and March 2019 were assigned to training or internal test dataset, and external test dataset was acquired from The Cancer Genome Atlas-Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) database. The effects of different methodologies on the performance of DL-model, including image cropping (IC), setting the attention level, selecting model complexity (MC), and applying transfer learning (TL), were compared using repeated measures analysis of variance (ANOVA) and receiver operating characteristic (ROC) curve analysis. The performance of DL-model was evaluated through accuracy and ROC analyses with internal and external tests. In this retrospective study, patients (n = 390) from one hospital were randomly assigned to training (n = 370) or internal test dataset (n = 20), and the other 20 patients from TCGA-KIRC database were assigned to external test dataset. IC, the attention level, MC, and TL had major effects on the performance of the DL-model. The DL-model based on the cropping o...Continue Reading

References

Sep 24, 1999·The Urologic Clinics of North America·N S Goldstein
Jun 6, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Brett Delahunt
Jul 26, 2013·Journal of Digital Imaging·Kenneth ClarkFred Prior
Sep 13, 2013·The American Journal of Surgical Pathology·Brett DelahuntUNKNOWN Members of the ISUP Renal Tumor Panel
Mar 7, 2014·Seminars in Interventional Radiology·Elaine M Caoili, Matthew S Davenport
May 29, 2015·Nature·Yann LeCunGeoffrey Hinton
May 29, 2018·European Journal of Radiology·Jiule DingWei Xing
Nov 19, 2018·Translational Oncology·Leilei ZhouHong-Bing Jiang
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 19, 2019·Polish journal of radiology·Ahmet AslanAli Yıkılmaz
Feb 8, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Zhan FengZhengyu Hu
Apr 13, 2019·Scientific Reports·Hisham AbdeltawabAyman El-Baz
May 18, 2019·Journal of Digital Imaging·Seokmin HanHak Jong Lee

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