A CT perfusion based model predicts outcome in wake-up stroke patients treated with recombinant tissue plasminogen activator.

Physiological Measurement
Miloš AjčevićMarcello Naccarato

Abstract

Advanced neuroimaging has proved to be pivotal in the management of acute ischemic stroke. The use of CT perfusion (CTP) core and penumbra parameters to predict the outcome in wake-up stroke (WUS) patients in everyday clinical scenarios has not yet been investigated. The aim of our study was to investigate the predictive power of CTP parameters on functional and morphological outcomes in WUS patients treated with recombinant tissue plasminogen activator (rTPA). We analyzed clinical data and processed CTP images of 83 consecutive WUS patients treated with rTPA. The predictive power of whole-brain CTP features and of the clinical stroke-related parameters to predict the National Institutes of Health Stroke Scale (NIHSS) score at the seventh day and ischemic lesion volume outcome was investigated by means of multivariate regression analysis as well as least absolute shrinkage and selection operator (LASSO) modeling. Multivariate analysis showed that CTP core volume (β = 0.403, p = 0.000), NIHSS at admission (β = 0.323, p = 0.005) and Alberta Stroke Program Early CT (ASPECT) score (β = -0.224, p = 0.012) predict NIHSS at 7 days, while total hypoperfused volume (β = 0.542, p = 0.000) and core volume on CTP (β =0.441, p = 0.000) pred...Continue Reading

References

Sep 27, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·C A Lewandowski, R Libman
Sep 26, 2008·The New England Journal of Medicine·Werner HackeUNKNOWN ECASS Investigators
May 11, 2011·Neurology·J MackeyJ P Broderick
Aug 4, 2012·Stroke; a Journal of Cerebral Circulation·Bruce C V CampbellMark W Parsons
Oct 25, 2012·Stroke; a Journal of Cerebral Circulation·Dong-Wha KangJong S Kim
Mar 16, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Götz ThomallaUNKNOWN WAKE-UP investigators
Nov 11, 2014·Annals of Neurology·Erin Burke QuinlanSteven C Cramer
Aug 20, 2015·The Neurohospitalist·Mark N Rubin, Kevin M Barrett
Jan 21, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jai Jai Shiva ShankarStephen Phillips
Dec 1, 2014·Journal of Neurology and Neurological Disorders·M C DennyS Martin-Schild
Feb 19, 2016·Journal of Neurointerventional Surgery·Ferdinand K HuiShazam Hussain
Jun 9, 2016·Annals of Neurology·Andrew D BarretoUNKNOWN Wake-Up Stroke Investigators
Jan 4, 2017·Brain : a Journal of Neurology·Hiroyuki KawanoMark W Parsons
Jan 10, 2017·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Shadi YaghiBernadette Boden-Albala
Sep 14, 2017·Journal of Neurointerventional Surgery·Won Hyung A RyuSteven W Hetts
Oct 22, 2017·European Journal of Radiology·Pedro Vilela, Howard A Rowley
Nov 14, 2017·The New England Journal of Medicine·Raul G NogueiraUNKNOWN DAWN Trial Investigators
Jan 25, 2018·The New England Journal of Medicine·Gregory W AlbersUNKNOWN DEFUSE 3 Investigators
Feb 23, 2018·Frontiers in Neurology·Andrew BivardMark William Parsons
May 5, 2018·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Giovanni FurlanisPaolo Manganotti
May 17, 2018·The New England Journal of Medicine·Götz ThomallaUNKNOWN WAKE-UP Investigators
Jul 11, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Paola CarusoPaolo Manganotti
Sep 20, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Marta Olive-GadeaMarta Rubiera
May 9, 2019·The New England Journal of Medicine·Henry MaUNKNOWN EXTEND Investigators
Jul 20, 2019·Seizure : the Journal of the British Epilepsy Association·Paolo ManganottiMarcello Naccarato
Aug 15, 2019·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Lara StragapedePaolo Manganotti
Sep 4, 2019·The Neurologist·Paola CarusoPaolo Manganotti
Nov 14, 2019·Journal of Neurology·Giovanni FurlanisPaolo Manganotti

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Citations

Feb 4, 2021·Neuroradiology·Giovanni FurlanisPaolo Manganotti
Dec 5, 2020·Medical & Biological Engineering & Computing·Miloš AjčevićPaolo Manganotti
Mar 2, 2021·The Neurologist·Roberta A Pozzi-MucelliMaria A Cova
Jun 3, 2021·International Journal of Environmental Research and Public Health·Sang Joon AnDoo-Young Kim
Jul 15, 2021·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Tommaso CillottoPaolo Manganotti

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