A cumulative experience examining the effect of natural and synthetic antimicrobial peptides vs. Chlamydia trachomatis

The Journal of Peptide Research : Official Journal of the American Peptide Society
B YasinE A Wagar

Abstract

We tested the activity of 48 structurally diverse antimicrobial peptides against Chlamydia trachomatis, serovar L2. The peptides' activity against C. trachomatis, serovar L2 was measured in 48-h McCoy cell shell vial assays. Peptides of 16-20 amino acids were more active than larger peptides, such as defensins. Beta-sheet protegrins, as well as alpha-helical peptides such as novispirin (G-10) were equally active. Enantiomers were as active as native structures. Moderate-sized circular mini-defensins were less effective against C. trachomatis. Moderate-sized cationic peptides may be useful in microbicide preparations designed to prevent chlamydial infection.

References

Oct 1, 1985·The Journal of Clinical Investigation·M E SelstedR I Lehrer
Dec 4, 1995·FEBS Letters·L BagellaM Zanetti
Jul 17, 1995·FEBS Letters·K W BenschW G Forssmann
Jun 1, 1994·International Journal of Peptide and Protein Research·Y AboudyM Fridkin
Jan 1, 1994·Methods in Enzymology·S S HarwigR I Lehrer
Apr 15, 1994·Biochemical and Biophysical Research Communications·D D OurthH E Renis
Apr 1, 1996·Infection and Immunity·X D QuR I Lehrer
Mar 1, 1996·Infection and Immunity·B YasinE A Wagar
May 5, 2000·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B YasinE A Wagar
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alexander M ColeRobert I Lehrer
Feb 22, 2002·European Journal of Biochemistry·Brian F TackRobert I Lehrer
May 29, 2003·Current Pharmaceutical Design·Alexander M Cole, Robert I Lehrer
Jun 13, 2003·Folia Microbiologica·P SímaK Sigler

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Citations

Dec 18, 2010·Nature Reviews. Microbiology·Julian G HurdleRichard E Lee
Oct 19, 2016·Microorganisms·Mika A BrownNam-Joon Cho
Aug 23, 2006·Chemical Biology & Drug Design·Olivier TaboureauHans-Henrik Kristensen
Oct 12, 2013·Expert Review of Anti-infective Therapy·Antonietta Di FrancescoManuela Donati

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