A cytochrome P4502E1 genetic polymorphism and tobacco smoking in breast cancer

Molecular Carcinogenesis
P G ShieldsJ L Freudenheim

Abstract

Known breast-cancer risk factors account for only part of the variability in breast-cancer incidence. Tobacco smoke is not commonly considered a breast carcinogen, but many of its constituents, such as N-nitrosamines, are carcinogenic in laboratory animal studies. Herein, we assessed a cytochrome P4502E1 (CYP2E1) genetic polymorphism (a Dral restriction enzyme site in intron 6) as a risk factor for breast cancer in both premenopausal and postmenopausal women. Because N-nitrosamines are metabolically activated by CYP2E1, the risk among women smokers was investigated. Caucasian women were enrolled in a case-control study of breast cancer between 1986 and 1991. A subset of the women (219 premenopausal and 387 postmenopausal women) consented to phlebotomy. The allelic frequencies for the premenopausal women (D allele = 0.91 and C allele = 0.09) and postmenopausal women (D allele = 0.93 and C allele = 0.07) were similar to those previously reported. There was no statistically significant association between the CYP2E1 polymorphism and breast-cancer risk for premenopausal or postmenopausal women (adjusted odds ratio (OR) = 1.04, 95% confidence interval (CI) = 0.48, 2.24, and OR = 1.01, 95% CI = 0.55, 1.84, respectively). When the wom...Continue Reading

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Citations

Nov 7, 2003·The Lancet Oncology·Pankaj Chaturvedi
Feb 26, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Pat NeafseyBabasaheb Sonawane
Jan 8, 2004·Journal of the National Cancer Institute·Peggy ReynoldsArgyrios Ziogas
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Apr 15, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Paul D Terry, Michael Goodman

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