PMID: 8943001Nov 26, 1996Paper

A cytokine mRNA-destabilizing element that is structurally and functionally distinct from A+U-rich elements

Proceedings of the National Academy of Sciences of the United States of America
C Y BrownG J Goodall

Abstract

The control of mRNA stability is crucial to the regulation of cytokine expression. We describe here a novel, potent destabilizing element found in the 3' untranslated region of granulocyte colony-stimulating factor mRNA. This element, which appears to require at least one stem-loop structure, we term the stem-loop destabilizing element (SLDE). Functionally equivalent elements appear to also exist in the interleukin 2 and interleukin 6 mRNAs. The SLDE is functionally distinct from the A+U-rich elements, which are also present in these and other cytokine mRNAs, because it destabilizes a chimeric mRNA in a tumor cell line in which A+U-rich elements do not function. In addition, the effect of the SLDE is insensitive to calcium ionophore and is therefore regulated independently of A+U destabilizing elements. The existence of two distinct mRNA-destabilizing elements provides an additional mechanism for the differential regulation of cytokine expression.

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Citations

Nov 30, 2002·Biochimie·Hélène TourrièreJamal Tazi
Mar 20, 2008·Nature Immunology·Paul Anderson
Jul 14, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L D SpotilaA Tenenhouse
Nov 28, 2002·Biological Chemistry·Lars Hareng, Thomas Hartung
Jan 13, 2015·Journal of Diabetes and Metabolic Disorders·Iqra HameedBashir A Ganai
Jan 5, 2010·Fish & Shellfish Immunology·Pengfei KongLinsheng Song
Apr 5, 2013·Immunological Reviews·Pavel Ivanov, Paul Anderson
Oct 1, 2011·Wiley Interdisciplinary Reviews. RNA·Johanna Schott, Georg Stoecklin
Apr 6, 2005·Biochemical and Biophysical Research Communications·Anja BergerGeorg Nickenig
May 22, 2004·Journal of Atherosclerosis and Thrombosis·Kanako NishikaiTakao Saruta
Apr 8, 2004·Developmental Cell·Masao KakokiOliver Smithies
Jan 1, 2011·Genetics Research International·T D MatosG Fialho
Sep 2, 1998·Immunology and Cell Biology·A Kelso
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B BarnhartL R Covey
Mar 19, 2020·Molecular Medicine Reports·Li LiuXiangyang Xiong
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ulus AtasoyCristiana Stellato
Jun 13, 2001·American Journal of Physiology. Cell Physiology·D A RicuperoR H Goldstein
Jan 29, 2021·Immunological Reviews·Emina DžafoSilvia Monticelli
Mar 17, 1999·Methods : a Companion to Methods in Enzymology·G M Wilson, G Brewer
Feb 5, 1999·Biochimica Et Biophysica Acta·M A ThomasC J Sanderson
Aug 23, 2011·Methods : a Companion to Methods in Enzymology·Jennifer A CorcoranCraig McCormick

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