A cytoplasmic factor involved in the expression of resistance to C8-ATC in Saccharomyces cerevisiae

Journal of Basic Microbiology
M H Misiewicz, Z Kotylak

Abstract

A dozen mutants of Saccharomyces cerevisiae, resistant to C8-ATC have been characterized. C8-ATC was previously established as a biologically toxic compound. Frequency of mutants (10(-7)) was typical for spontaneous mutations. One very stable mutant was characterized extensively. The genetical analysis revealed that resistance in this mutant was determined by single-gene mutation. The rho 0 cells, obtained by ethidium bromide (EB) mutagenesis of the resistant strain, were completely devoid of resistance. A large percentage of rho- cells, obtained by a moderate EB treatment of resistant cells were still able to express resistance to C8-ATC. Therefore we hypothesized that, in our particular strain, a cytoplasmic factor is involved in nuclear determination of resistance.

References

Apr 6, 1978·Molecular & General Genetics : MGG·A Kruszewska, B Szcześniak
Jan 1, 1974·Molecular & General Genetics : MGG·A M ColsonJ R Mattoon

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Citations

Oct 14, 2006·Journal of the American Geriatrics Society·Alberto PilottoFrancesco Di Mario

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