PMID: 11607549Jun 20, 1995Paper

A cytoplasmically transmissible hypovirulence phenotype associated with mitochondrial DNA mutations in the chestnut blight fungus Cryphonectria parasitica

Proceedings of the National Academy of Sciences of the United States of America
Claudia B Monteiro-VitorelloH Bertrand

Abstract

Mutations causing mitochondrial defects were induced in a virulent strain of the chestnut blight fungus Cryphonectria parasitica (Murr.) Barr. Virulence on apples and chestnut trees was reduced in four of six extensively characterized mutants. Relative to the virulent progenitor, the attenuated mutants had reduced growth rates, abnormal colony morphologies, and few asexual spores, and they resembled virus-infected strains. The respiratory defects and attenuated virulence phenotypes (hypovirulence) were transmitted from two mutants to a virulent strain by hyphal contact. The infectious transmission of hypovirulence occurred independently of the transfer of nuclei, did not involve a virus, and dynamically reflects fungal diseases caused by mitochondrial mutations. In these mutants, mitochondrial mutations are further implicated in generation of the attenuated state by (i) uniparental (maternal) inheritance of the trait, (ii) presence of high levels of cyanide-insensitive mitochondrial alternative oxidase activity, (iii) cytochrome deficiencies, and (iv) structural abnormalities in the mtDNA. Hence, cytoplasmically transmissible hypovirulence phenotypes found in virus-free strains of C. parasitica from recovering trees may be caus...Continue Reading

References

Jan 1, 1992·Annual Review of Genetics·A J Griffiths
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·H BertrandA M Lambowitz

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Citations

Aug 3, 2005·Nature Reviews. Microbiology·Donald L Nuss
Feb 3, 2000·Molecular Plant-microbe Interactions : MPMI·D BaidyaroyH Bertrand
Jun 7, 2014·Current Opinion in Microbiology·Laurent Chatre, Miria Ricchetti
Jan 3, 2006·Fungal Genetics and Biology : FG & B·Georg HausnerHelmut Bertrand
Jun 18, 2020·Frontiers in Microbiology·Rocio MedinaPedro Alberto Balatti
Jul 18, 2009·Fungal Genetics and Biology : FG & B·Claudia B Monteiro-VitorelloHelmut Bertrand
Oct 8, 2021·Frontiers in Microbiology·Runmao LinAiping Zheng
May 31, 2011·Fungal Genetics and Biology : FG & B·Dipnath BaidyaroyHelmut Bertrand

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