A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin.

Nature
J J SiekierkaN H Sigal

Abstract

CYCLOSPORIN A and the newly discovered immunosuppressant, FK-506, are potent inhibitors of T cell activation. In addition to their clinical importance in the prevention of allograft rejection, cyclosporin A and FK-506 represent important reagents for the study of the molecular mechanisms of lymphocyte activation. Cyclosporin A, a cyclic undecapeptide and FK-506, a macrolide, although chemically distinct, inhibit similar lymphocyte activation responses. The earliest responses inhibited in the T cell seem to be the expression of early phase T cell-activation genes for interleukins 2, 3 and 4, granulocyte-macrophage colony stimulating factor and gamma interferon. Although FK-506 and cyclosporin A seem to inhibit similar signal transduction processes, they do so be interacting with distinct cytosolic proteins. We report here the purification to homogeneity of a specific FK-506 binding protein that is distinct from the cyclosporin A-binding protein, cyclophilin. In addition, we show that this FK-506 binding protein, like cyclophilin, has peptidyl-prolyl isomerase activity.

References

May 1, 1988·DNA·P E DanielsonJ G Sutcliffe
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C J Brandl, C M Deber
Nov 2, 1984·Science·R E HandschumacherD W Speicher
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M KrönkeW C Greene

❮ Previous
Next ❯

Citations

May 16, 1990·JAMA : the Journal of the American Medical Association·T E Starzl, J J Fung
Jul 4, 1990·JAMA : the Journal of the American Medical Association·T E StarzlM Alessiani
Nov 1, 1996·Journal of Cellular Biochemistry·X WangJ Wu
Jul 18, 2001·Annals of Neurology·X GuoT M Dawson
Apr 1, 1992·Biopolymers·A PolinskyC M Deber
Jul 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A FrancavillaS Todo
May 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A FrancavillaQ H Zeng
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C R GandhiT E Starzl
Jul 1, 1992·Medicinal Research Reviews·M D Walkinshaw
May 1, 1993·Medicinal Research Reviews·R A Wiley, D H Rich
Jul 20, 2000·Archives of Biochemistry and Biophysics·M LeclercqA Galat
Jul 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·K Wenzel-Seifert, R Seifert
Jan 1, 1993·Transplant International : Official Journal of the European Society for Organ Transplantation·S V McDiarmidR W Busuttil
Jun 1, 1992·Journal of Protein Chemistry·R EdaljiT F Holzman
Jan 1, 1993·European Journal of Pediatrics·R SelbyR S Kendall
Nov 1, 1992·Journal of Biomolecular NMR·E T OlejniczakS W Fesik
Dec 13, 1997·Molecular Neurobiology·D M SabatiniS H Snyder
Feb 11, 1998·Molecular Neurobiology·B G Gold
Jan 1, 1995·Folia Microbiologica·Z Rehácek
Apr 8, 2006·Analytical and Bioanalytical Chemistry·Teruki TakahashiAkito Tanaka
May 24, 2007·Cancer Chemotherapy and Pharmacology·Shuai ChenLong Yu
Apr 6, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Stuart L RultenJohn E Kay
Apr 5, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Irina S BarequetZohar Habot-Wilner
Jul 27, 2005·Pflügers Archiv : European journal of physiology·Tom NijenhuisRené J M Bindels
Jan 10, 2008·Pharmaceutical Research·Masato MitsuhashiAtsushi Shinagawa
Apr 19, 2011·Targeted Oncology·Kevin R KellyJennifer S Carew
Jan 23, 2009·Cell Biochemistry and Biophysics·Srikanth PaturyJason E Gestwicki
Feb 13, 2010·Molecular Biotechnology·W Frank An, Nicola Tolliday
Oct 1, 1994·Clinical Biochemistry·J G Donnelly, S J Soldin
Jan 1, 1996·Life Sciences·F J Dumont, Q Su
Nov 1, 1991·Mutation Research·H S Rosenkranz, G Klopman
Jan 1, 1995·Progress in Biophysics and Molecular Biology·A Galat, S M Metcalfe
Jan 1, 1991·Molecular Aspects of Medicine·D WestmacottA D Sedgwick
Jan 5, 1991·Lancet·A M Macleod, A W Thomson

❮ Previous
Next ❯

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