A cytotoxic cyclic heptapeptide from the seeds of Annona cherimola

Journal of Natural Products
Alassane WéléBernard Bodo

Abstract

From a methanol extract of the seeds of Annona cherimola, a new cyclic heptapeptide, cherimolacyclopeptide C, has been isolated. The structure was elucidated on the basis of the MS/MS fragmentation using a Q-TOF mass spectrometer equipped with an ESI source, extensive 2D NMR experiments, and chemical degradation. Cherimolacyclopeptide C exhibited significant in vitro cytotoxic activity against KB cells, with an IC(50) value of 0.072 microM.

Citations

Jun 1, 2005·Phytochemistry·Alassane WéléBernard Bodo
Nov 29, 2005·Natural Product Reports·Tomomi Kawasaki, Kazuhiro Higuchi
Aug 21, 2013·Journal of Asian Natural Products Research·M Rajeswari Prabha, B Ramachandramurty
May 3, 2006·Chemical & Pharmaceutical Bulletin·Alassane WeleBernard Bodo
Mar 20, 2013·International Journal of Peptides·M Rajeswari Prabha, B Ramachandramurty
Mar 31, 2015·BioMed Research International·Jaquelina Julia Guzmán-RodríguezJoel E López-Meza
Apr 16, 2016·Journal of Natural Products·Pâmela J Dos S BeirigoVirgínia C da Silva
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Jan 22, 2014·Food Chemistry·Ping WuXiaoyi Wei
Jul 26, 2005·Phytochemistry·Alassane WéléBernard Bodo
Mar 18, 2005·Phytochemistry·Alassane WéléBernard Bodo
Jan 29, 2019·Current Topics in Medicinal Chemistry·Shams AaghazAhmed Kamal
Nov 13, 2018·Plant Direct·Mark F FisherJoshua S Mylne
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Feb 5, 2021·European Journal of Medicinal Chemistry·Rajiv Dahiya, Sunita Dahiya
Feb 16, 2021·Journal of Peptide Science : an Official Publication of the European Peptide Society·Yuka YoshidaYuichi Masuda
Jan 8, 2008·Journal of Natural Products·George R PettitJean-Charles Chapuis
May 1, 2021·International Journal of Molecular Sciences·Jia-Nan ZhangHong-Jie Zhang
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Aug 9, 2019·Journal of Natural Products·Mark F FisherJoshua S Mylne
Aug 7, 2007·Journal of Natural Products·Simone Quintyne-WalcottWilliam F Reynolds

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