PMID: 16509530Mar 3, 2006Paper

A daily comprehensive muscle training programme increases lean mass and spontaneous activity in children with Prader-Willi syndrome after 6 months

Journal of Pediatric Endocrinology & Metabolism : JPEM
Michael SchlumpfD l'Allemand

Abstract

The reduction of spontaneous physical activity (PA) and of muscle tissue are thought to be major causes of fat accretion and metabolic deterioration in Prader-Labhart-Willi syndrome (PWS). We investigated whether a generalized physical training programme in a home setting improves these parameters. The prospective study included 11 prepubertal children (mean age 8.7 years, range 5.9-11.8) with documented PWS and under continuous growth hormone treatment for at least 2.8 years. Seven children were enrolled in a training programme for several muscle groups during 4-10 minutes daily. Twelve matched children with PWS served as controls (average age 8.8 years, 6.1-11.3). Before and after training, at 6 months, PA was assessed by measuring walking distance by pedometer registration and by an activity score, and body composition by DEXA expressed as standard deviation scores (SDS) related to height. After training, lean mass (LM) increased from -1.83 to -1.48 SDS, p <0.05, whereas the controls showed no change. In the training group, walking distance and PA increased from 4.2 to 4.7 km/d and from 255 to 266 points, respectively, and these rises significantly exceeded those observed in controls. Children with PWS can be motivated by th...Continue Reading

Associated Clinical Trials

References

Feb 14, 1998·European Journal of Pediatrics·E HershkovitzM Phillip

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Citations

Nov 15, 2011·Endocrine·Rasmus Sode-CarlsenCharlotte Höybye
May 8, 2009·BMC Musculoskeletal Disorders·Paolo CapodaglioGraziano Grugni
May 30, 2009·Disability and Rehabilitation·Rasmus Sode-CarlsenCharlotte Höybye
Jun 2, 2012·Neuroscience and Biobehavioral Reviews·Linda ReusMaria W G Nijhuis-van der Sanden
Aug 19, 2014·Research in Developmental Disabilities·Diobel M CastnerDaniela A Rubin
Jul 30, 2010·Research in Developmental Disabilities·Luca VismaraPaolo Capodaglio
Nov 9, 2010·Neuroscience and Biobehavioral Reviews·Linda ReusMaria W G Nijhuis-van der Sanden
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Apr 15, 2008·Journal of Developmental and Behavioral Pediatrics : JDBP·Natalie Vona MessersmithKimberly Bellipanni
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Nov 9, 2018·Medicine and Science in Sports and Exercise·Daniela A RubinDebra J Rose
Feb 23, 2019·Clinical Endocrinology·Javier S MoralesAlejandro Lucia
Dec 14, 2011·The Journal of Clinical Endocrinology and Metabolism·Thomas EdouardNathalie Alos
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