A Dairy-Derived Ghrelinergic Hydrolysate Modulates Food Intake In Vivo

International Journal of Molecular Sciences
Ken HowickHarriët Schellekens

Abstract

Recent times have seen an increasing move towards harnessing the health-promoting benefits of food and dietary constituents while providing scientific evidence to substantiate their claims. In particular, the potential for bioactive protein hydrolysates and peptides to enhance health in conjunction with conventional pharmaceutical therapy is being investigated. Dairy-derived proteins have been shown to contain bioactive peptide sequences with various purported health benefits, with effects ranging from the digestive system to cardiovascular circulation, the immune system and the central nervous system. Interestingly, the ability of dairy proteins to modulate metabolism and appetite has recently been reported. The ghrelin receptor (GHSR-1a) is a G-protein coupled receptor which plays a key role in the regulation of food intake. Pharmacological manipulation of the growth hormone secretagogue receptor-type 1a (GHSR-1a) receptor has therefore received a lot of attention as a strategy to combat disorders of appetite and body weight, including age-related malnutrition and the progressive muscle wasting syndrome known as cachexia. In this study, a milk protein-derivative is shown to increase GHSR-1a-mediated intracellular calcium sign...Continue Reading

References

Mar 25, 1999·International Journal of Pharmaceutics·C TuleuJ C Chaumeil
Nov 1, 2000·Nature·M TschöpM L Heiman
Dec 12, 2001·The Journal of Clinical Endocrinology and Metabolism·A M WrenS R Bloom
Mar 9, 2002·Methods in Enzymology·Antonia Follenzi, Luigi Naldini
May 29, 2003·Current Pharmaceutical Design·H Korhonen, A Pihlanto
Jul 21, 2004·Best Practice & Research. Clinical Endocrinology & Metabolism·Ian McPhee Chapman
Feb 13, 2007·Current Opinion in Biotechnology·Rainer Hartmann, Hans Meisel
Aug 30, 2008·Nutrition·Mark Daniel DeBoer
Jul 23, 2011·Food & Function·Martha Phelan, David Kerins
Mar 27, 2012·PloS One·Harriët SchellekensJohn F Cryan
Nov 20, 2012·The Journal of Biological Chemistry·Harriët SchellekensJohn F Cryan
Feb 28, 2013·Therapeutic Delivery·David J Brayden, Alan W Baird
Nov 29, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hironobu TsubouchiMasamitsu Nakazato
Dec 19, 2013·American Journal of Physiology. Endocrinology and Metabolism·Kiyoshi TerawakiYasuhito Uezono
Mar 14, 2014·Nutritional Neuroscience·Cristina Torres-FuentesJohn F Cryan
Dec 30, 2014·Frontiers in Pharmacology·Naoki Fujitsuka, Yasuhito Uezono
Jun 5, 2015·Molecular Metabolism·T D MüllerM H Tschöp
Oct 28, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Antonello SantiniEttore Novellino
Nov 8, 2016·Scientific Reports·Elena Pastor-CavadaHarriet Schellekens
Jan 31, 2017·International Journal of Molecular Sciences·Ken HowickHarriët Schellekens
Mar 23, 2017·American Journal of Physiology. Endocrinology and Metabolism·Kanishka N NilaweeraPaul D Cotter
Apr 19, 2018·Expert Review of Clinical Pharmacology·Antonello Santini, Ettore Novellino

❮ Previous
Next ❯

Citations

Nov 27, 2020·International Journal of Molecular Sciences·Giovanni Tulipano

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
Size exclusion chromatography
Assay
Transfection
flow cytometry

Software Mentioned

CasHyd
GraphPAD
Excel
GraphPad Prism

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

© 2022 Meta ULC. All rights reserved