A Data Integration Multi-Omics Approach to Study Calorie Restriction-Induced Changes in Insulin Sensitivity

Frontiers in Physiology
Maria Carlota DaoMICRO-Obes Consortium

Abstract

Background: The mechanisms responsible for calorie restriction (CR)-induced improvement in insulin sensitivity (IS) have not been fully elucidated. Greater insight can be achieved through deep biological phenotyping of subjects undergoing CR, and integration of big data. Materials and Methods: An integrative approach was applied to investigate associations between change in IS and factors from host, microbiota, and lifestyle after a 6-week CR period in 27 overweight or obese adults (ClinicalTrials.gov: NCT01314690). Partial least squares regression was used to determine associations of change (week 6 - baseline) between IS markers and lifestyle factors (diet and physical activity), subcutaneous adipose tissue (sAT) gene expression, metabolomics of serum, urine and feces, and gut microbiota composition. ScaleNet, a network learning approach based on spectral consensus strategy (SCS, developed by us) was used for reconstruction of biological networks. Results: A spectrum of variables from lifestyle factors (10 nutrients), gut microbiota (10 metagenomics species), and host multi-omics (metabolic features: 84 from serum, 73 from urine, and 131 from feces; and 257 sAT gene probes) most associated with IS were identified. Biological ...Continue Reading

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Citations

Nov 12, 2019·The FEBS Journal·Jordi Mayneris-Perxachs, José-Manuel Fernández-Real
Jan 1, 2020·Antioxidants & Redox Signaling·Xin HuDean P Jones
Jul 28, 2020·Frontiers in Oncology·Marco ChiericiCesare Furlanello
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Oct 18, 2020·Nutrients·Leila KhorraminezhadIwona Rudkowska
Nov 12, 2019·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Martina Palomino-SchätzleinJosé-Manuel Fernández-Real
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Nov 20, 2020·Scientific Reports·Rikke Linnemann NielsenRamneek Gupta
Dec 5, 2020·International Journal of Molecular Sciences·Maria V DeligiorgiDimitrios T Trafalis
Dec 9, 2020·International Journal of Molecular Sciences·Carla Almendáriz-PalaciosZoe E Gillespie
Mar 4, 2021·Nutrients·Manuela CassottaMaurizio Battino

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Methods Mentioned

BETA
X-ray
Biopsies
biopsy
PCR
NMR
gastric bypass
ubiquitination

Clinical Trials Mentioned

NCT01314690

Software Mentioned

Cytoscape
Obes
ScaleNet
XCMS R
Omics Data Integration Project )
Automated Mass Spectral Deconvolution and Identification Syste...
FunNet
SAS
R “ mixOmics ” package (
Metabolights

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