A Data Science-Based Analysis Points at Distinct Patterns of Lipid Mediator Plasma Concentrations in Patients With Dementia

Frontiers in Psychiatry
Robert GurkeJörn Lötsch

Abstract

Based on accumulating evidence of a role of lipid signaling in many physiological and pathophysiological processes including psychiatric diseases, the present data driven analysis was designed to gather information needed to develop a prospective biomarker, using a targeted lipidomics approach covering different lipid mediators. Using unsupervised methods of data structure detection, implemented as hierarchal clustering, emergent self-organizing maps of neuronal networks, and principal component analysis, a cluster structure was found in the input data space comprising plasma concentrations of d = 35 different lipid-markers of various classes acquired in n = 94 subjects with the clinical diagnoses depression, bipolar disorder, ADHD, dementia, or in healthy controls. The structure separated patients with dementia from the other clinical groups, indicating that dementia is associated with a distinct lipid mediator plasma concentrations pattern possibly providing a basis for a future biomarker. This hypothesis was subsequently assessed using supervised machine-learning methods, implemented as random forests or principal component analysis followed by computed ABC analysis used for feature selection, and as random forests, k-neares...Continue Reading

References

Apr 28, 1995·Journal of Molecular Biology·E KaufmannW Knöchel
Mar 1, 1997·Journal of Biopharmaceutical Statistics·L F LaceyA Bye
Sep 13, 2003·Journal of Biomedical Informatics·Stephan Dreiseitl, Lucila Ohno-Machado
Jul 30, 2005·Nature Reviews. Drug Discovery·Markus R Wenk
Mar 1, 2006·BMC Bioinformatics·Sudhir Varma, Richard Simon
Jan 2, 2007·Journal of Traumatic Stress·Jeffrey S Hoch, Mark W Smith
Aug 28, 2007·Bioinformatics·Yvan SaeysPedro Larrañaga
Feb 26, 2011·Journal of Pharmacology & Pharmacotherapeutics·S Manikandan
Mar 19, 2011·BMC Bioinformatics·Xavier RobinMarkus Müller
Jul 12, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul L Wood
Jan 30, 2014·Nature Neuroscience·Daniele Piomelli, Oscar Sasso
Jun 4, 2015·Pharmacology Research & Perspectives·Ron J KeizerAlwin D R Huitema
Aug 2, 2015·Analytica Chimica Acta·Antonio ChecaJoaquim Jaumot
Aug 13, 2015·Scientific Reports·Chenyue W HuAmina A Qutub
Nov 12, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Sumit SethiElisa Brietzke
Jun 22, 2016·Bioanalysis·Isabelle KohlerMartin Giera
Jul 28, 2016·Analytical and Bioanalytical Chemistry·Xinyu LiuGuowang Xu
Oct 30, 2016·Trends in Biochemical Sciences·Kui Yang, Xianlin Han
Jan 1, 2017·Prostaglandins & Other Lipid Mediators·Sumit Sethi, Elisa Brietzke
Jan 4, 2017·Journal of Biomedical Informatics·Alfred Ultsch, Jörn Lötsch

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Citations

Apr 5, 2020·International Journal of Molecular Sciences·Katja JakobiGeorgios Grammatikos
Jul 25, 2019·International Journal of Molecular Sciences·Luciana M Pujol-Lereis
Oct 2, 2021·CPT: Pharmacometrics & Systems Pharmacology·Sebastian MalkuschJörn Lötsch

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Methods Mentioned

BETA
PCA
feature extraction
sedation

Software Mentioned

R
R library cluster
pROC
progenyClust
R package “ klaR
R script
R library
R package “ Umatrix ” Umatrix
R library “
Umatrix

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