A database analysis of jacalin-like lectins: sequence-structure-function relationships

Glycobiology
Sujana RavalNagasuma R Chandra

Abstract

Lectins are known to be important for many biological processes, due to their ability to recognize cell surface carbohydrates with high specificity. Plant lectins have been model systems to study protein-carbohydrate recognition, because individually they exhibit high sensitivity and as a group large diversity in recognizing carbohydrate structures. Although extensive studies have been carried out for legume lectins that have led to interesting insights into the sequence determinants of sugar recognition in them, frameworks with such specific correlations are not available for other plant lectin families. This study reports a large-scale data acquisition and extensive analysis of sequences and structures of beta-prism-I or jacalin-related lectins (JRLs) and shows that hypervariability in the binding site loops generates carbohydrate recognition diversity, a strategy analogous to that in legume lectins. Analyses of the size, conformation, and sequence variability in key regions reveal the existence of a common theme, encoded as a set of structural features over a common scaffold, in defining specificity. This study also points to the remarkable range of domain architectures, often arising out of gene duplication events in lectin...Continue Reading

Citations

Jan 1, 2009·Journal of the American Chemical Society·Emilio J CocineroJohn P Simons
May 16, 2009·Nature Reviews. Microbiology·Gerardo R Vasta
Aug 25, 2011·Journal of Experimental Botany·Yang XiangYun Wang
Jul 5, 2005·Plant Physiology·Huaijun Michael LiFaith C Belanger
May 6, 2011·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Ashok K PatelPetri Kursula
Oct 20, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Eric R SecorLawrence K Silbart
Mar 14, 2014·Current Microbiology·Mariana RegenteValdirene M Gomes
Aug 3, 2010·Expert Review of Vaccines·Antonio GranellDiego Orzáez
Nov 20, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Senjam Sunil SinghTzi Bun Ng
Sep 11, 2009·Journal of Photochemistry and Photobiology. B, Biology·Gunjan PandeySneha Sudha Komath
Apr 13, 2011·The FEBS Journal·Bassam Al AtalahEls J M Van Damme
Sep 9, 2006·Bioscience, Biotechnology, and Biochemistry·Tomokazu HaraguchiFumio Yagi
Feb 6, 2007·Molecular Immunology·Jennifer S MooreJan Novak
Mar 9, 2011·Genomics, Proteomics & Bioinformatics·Jun WangGane Ka-Shu Wong
Jul 18, 2006·Structure·Nagasuma Chandra
May 29, 2015·Biotechnology, Biotechnological Equipment·Xiao-Yu LiuWei Zhang
Aug 27, 2014·Bioscience, Biotechnology, and Biochemistry·Michiko ShimokawaJun Hirabayashi
Aug 16, 2016·Fish & Shellfish Immunology·Jun Cao, Yueqing Lv
Nov 2, 2016·Journal of Periodontal & Implant Science·Seok-Mo HeoSang Wook Oh
Apr 14, 2017·Molecular Reproduction and Development·Renato ZampiniSilvana A Apichela
Jun 20, 2006·Glycobiology·Nagasuma R ChandraM N Prathima
Jun 10, 2005·Glycobiology·Jennifer L MeagherJeanne A Stuckey
Oct 20, 2017·Frontiers in Pharmacology·Jannyson J B JandúLuís C N da Silva
Jul 21, 2017·The Plant Genome·Lore EggermontEls J M Van Damme
Sep 23, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Abtar MishraRohan Dhiman
Jun 25, 2015·Microbiology Spectrum·Jiunn N C Fong, Fitnat H Yildiz

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