A decade after the emergence of Candida auris: what do we know?

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Amira ElBaradei

Abstract

Candida auris is a remarkable emerging pathogen. It has emerged separately, yet simultaneously in different parts of the world, establishing four phylogenetic and geographic distinct clades with a potential fifth clade that was recently reported. C. auris is often perceived as a pathogen in disguise, due to its frequent misidentification and its immune evasion. On the other hand, many of the recovered isolates are multidrug-resistant. In fact, some of these isolates are resistant to the three main antifungal classes: echinocandins, azoles, and polyenes. Moreover, C. auris has the ability to persist and survive on different objects for a long time, aided by different adhering mechanisms including aggregation and biofilm formation, thereby causing outbreaks of invasive infections in hospital settings. However, C. auris ability to maintain its pathogenicity at high temperatures remains among its most unique properties. This is why C. auris represents a challenging threat, and more studies are needed to meet this challenge. This review highlights different characteristics of this emerging yeast with emphasis on its antifungal resistance, its ability to persistent on different surfaces, and its immune evasion capability.

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Citations

Sep 6, 2020·Antibiotics·María Guadalupe Frías-De-LeónErick Martínez-Herrera
Apr 29, 2021·Indian Journal of Medical Microbiology·Gurujala Mahadeva RamyaR UshaDevi
Jul 24, 2021·Indian Journal of Microbiology·Jacqueline Teixeira da SilvaAndre Correa Amaral
Aug 14, 2021·Journal de mycologie médicale·Beata ZatorskaElisabeth Presterl
Sep 11, 2021·Medical Mycology·Si Jie LimSiti Nurbaya Oslan
Nov 2, 2021·Frontiers in Cellular and Infection Microbiology·Dingchen LiLi Han
Dec 11, 2021·Emerging Microbes & Infections·Victor Garcia-BustosAmparo Ruiz-Saurí

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

MicroScan
Vitek

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