PMID: 11918505Mar 29, 2002Paper

A decade of antimicrobial susceptibilities at the University of Kentucky Hospital

The Annals of Pharmacotherapy
Robert P RappMartin E Evans

Abstract

To determine the antimicrobial susceptibility rates for key antimicrobial agents and selective bacterial pathogens in the decade of the 1990s. Data from 1990 to 2000 from the University of Kentucky Clinical Microbiology Laboratory were analyzed by linear regression analysis to identify agents and pathogens that show a decline in susceptibility. For selected pathogens and antimicrobial agents, predictions were made for further declines in susceptibility for 2005 and 2010. Significant declines in susceptibility to selected antimicrobial agents were found for Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter cloacae, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pneumoniae. Further declines were predicted for 2005 and 2010. Examination of susceptibility rates over time in a university hospital medical center provides useful data for future planning. In our institution, antimicrobial susceptibility rates have significantly declined during the 1990s for certain antimicrobial agents and bacterial pathogens. We are attempting to change our antimicrobial use patterns through formulary manipulation and clinician education, which may retard or prevent such declines in the future.

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Citations

Nov 19, 2013·The Journal of Thoracic and Cardiovascular Surgery·J Scott Rankin, Charles W Stratton
Jul 5, 2011·The Journal of Thoracic and Cardiovascular Surgery·J Scott RankinCharles W Stratton
May 4, 2004·Current Medical Research and Opinion·Robert P RappJohn A Armitstead
Mar 26, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Craig MartinMartin Evans

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