A decade of Burkholderia cenocepacia virulence determinant research.

Infection and Immunity
Slade A Loutet, Miguel A Valvano

Abstract

The Burkholderia cepacia complex (Bcc) is a group of genetically related environmental bacteria that can cause chronic opportunistic infections in patients with cystic fibrosis (CF) and other underlying diseases. These infections are difficult to treat due to the inherent resistance of the bacteria to antibiotics. Bacteria can spread between CF patients through social contact and sometimes cause cepacia syndrome, a fatal pneumonia accompanied by septicemia. Burkholderia cenocepacia has been the focus of attention because initially it was the most common Bcc species isolated from patients with CF in North America and Europe. Today, B. cenocepacia, along with Burkholderia multivorans, is the most prevalent Bcc species in patients with CF. Given the progress that has been made in our understanding of B. cenocepacia over the past decade, we thought that it was an appropriate time to review our knowledge of the pathogenesis of B. cenocepacia, paying particular attention to the characterization of virulence determinants and the new tools that have been developed to study them. A common theme emerging from these studies is that B. cenocepacia establishes chronic infections in immunocompromised patients, which depend more on determinan...Continue Reading

References

Feb 1, 1984·The Journal of Pediatrics·A IslesH Levison
Nov 1, 1996·FEMS Microbiology Letters·T G LessieR Devereux
Feb 7, 1998·Infection and Immunity·P DarlingP A Sokol
Sep 16, 1998·Antimicrobial Agents and Chemotherapy·J TurnerR I Lehrer
Jan 28, 1999·Journal of Bacteriology·S LewenzaP A Sokol
Sep 3, 1999·American Journal of Respiratory and Critical Care Medicine·S W StitesL J Wesselius
Feb 3, 2000·Journal of Clinical Microbiology·E MahenthiralingamP Vandamme
Mar 18, 2000·Infection and Immunity·U S SajjanJ F Forstner
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·S D AaronN E Macdonald
Aug 31, 2000·Applied and Environmental Microbiology·C C CainJ O Falkinham
Feb 7, 2001·Applied and Environmental Microbiology·J BalandreauP Vandamme
Feb 24, 2001·Ryōikibetsu shōkōgun shirīzu·M Iwata, H Nunoi
Apr 26, 2001·Environmental Microbiology·A G Kroon, C G van Ginkel
Jul 4, 2001·American Journal of Respiratory and Critical Care Medicine·J J LiPumaE Mahenthiralingam
Nov 23, 2001·Canadian Journal of Microbiology·K L TomlinH Ceri
Mar 16, 2002·Infection and Immunity·Mladen TomichChristian D Mohr
Mar 19, 2002·Emerging Infectious Diseases·David P SpeertEshwar Mahenthiralingam
Jun 5, 2002·Annual Review of Biochemistry·Christian R H Raetz, Chris Whitfield
Jun 22, 2002·Lancet·John J LiPumaCarlos F Gonzalez
Aug 6, 2002·The Journal of Antimicrobial Chemotherapy·Sazini NzulaJohn R W Govan
Sep 25, 2002·Journal of Bacteriology·Barbara-Ann D ConwayDavid P Speert
Oct 17, 2002·Canadian Journal of Microbiology·Shawn LewenzaPamela A Sokol

❮ Previous
Next ❯

Citations

Oct 15, 2011·Applied Microbiology and Biotechnology·Silvia BazziniGiovanna Riccardi
Feb 23, 2012·Antimicrobial Agents and Chemotherapy·César de la Fuente-NúñezRobert E W Hancock
Jun 5, 2013·Journal of Bacteriology·Christian G RamosJorge H Leitão
Dec 13, 2012·Future Microbiology·Sujatha Subramoni, Pamela A Sokol
Dec 10, 2013·Biochimica Et Biophysica Acta·Benjamin H SchwarzJeffrey M Watson
Mar 5, 2015·Pathogens·Louise Cullen, Siobhán McClean
Jan 14, 2011·Trends in Microbiology·Robert P Ryan, J Maxwell Dow
Jul 10, 2013·Journal of Molecular Recognition : JMR·Baddr ShakhsheerElaine Mullen
Jul 30, 2015·Canadian Journal of Microbiology·Miguel A Valvano
Apr 15, 2016·FEMS Microbiology Reviews·Rita F MaldonadoMiguel A Valvano
Mar 22, 2014·Critical Reviews in Microbiology·Susana P LopesMaria O Pereira
Jul 19, 2015·International Journal of Antimicrobial Agents·Slade A LoutetMiguel A Valvano
Sep 4, 2012·Pure and Applied Chemistry. Chimie Pure Et Appliquée·Alla ZamyatinaPaul Kosma
Apr 20, 2016·Vaccines·Gonzalo A PradenasAlfredo G Torres
Sep 7, 2016·Frontiers in Microbiology·Yee-Chin WongSheila Nathan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Related Papers

Nature Reviews. Microbiology
Eshwar MahenthiralingamJoanna B Goldberg
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Pavel Drevinek, Eshwar Mahenthiralingam
© 2021 Meta ULC. All rights reserved