A decade of modern epilepsy therapy in institutionalized mentally retarded patients

Epilepsy Research
J M Pellock, P A Hunt

Abstract

To evaluate epilepsy therapy in an institutionalized mentally retarded (MR) population involved in a long-term program to reduce anti-epilepsy drugs. An open 10-year study in 244 epileptic MR patients. An interim evaluation was performed in 1987 and a final evaluation in 1991. MR patients, with a history of symptomatic generalized and partial seizures, at Southside Virginia Training Center (SVTC), Virginia Department of Mental Health, Mental Retardation and Substance Abuse Services. In 1981, an evaluation was made of the clinical condition and anti-epilepsy drug (AED) therapy for each patient. AED therapy was tapered for patients who were seizure-free, performance-impairing agents were discontinued for patients receiving polytherapy, and therapy was re-evaluated for patients with poor seizure control. Adverse drug reactions were quantitatively assessed and sedative agents reduced. The staff was educated regarding identification of seizures and adverse drug reactions. A 19% reduction in polytherapy was accomplished. AEDs were discontinued in 12.7% of patients, however, nearly half required reinitiation of therapy. The percentage of patients receiving monotherapy increased from 36.5% to 58.1% with no observed loss in seizure cont...Continue Reading

References

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Citations

Dec 7, 2000·Mental Retardation and Developmental Disabilities Research Reviews·J M Pellock, L D Morton
Mar 12, 2003·Current Treatment Options in Neurology·John M. Pellock
May 21, 1998·Pharmacology & Therapeutics·J A Hannah, M J Brodie
Nov 26, 2002·Epilepsy Research·Dieter SchmidtGregory L Holmes
Nov 26, 2002·Epilepsy Research·Gregory L Holmes
Nov 26, 2002·Epilepsy Research·Blaise F D Bourgeois
Jan 15, 1999·Seizure : the Journal of the British Epilepsy Association·D BranfordR A Collacott
Apr 21, 1998·Seizure : the Journal of the British Epilepsy Association·J A Hannah, M J Brodie
Mar 1, 2003·Epilepsy & Behavior : E&B·John M. Pellock
Nov 18, 2000·Journal of Intellectual Disability Research : JIDR·C Bowley, M Kerr
Mar 24, 2006·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Stacey Allison Smith, Jerry R McKee
Oct 29, 2010·Developmental Disabilities Research Reviews·Dewi Frances T Depositario-Cabacar, Tesfaye-Getaneh Zelleke
Jun 14, 2000·Seizure : the Journal of the British Epilepsy Association·B E GidalP Rutecki
Sep 2, 2008·Seizure : the Journal of the British Epilepsy Association·Bernd HuberM Seidel
Jan 16, 1998·Journal of Child Neurology·T R Sunder

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