A decade of pharmacogenomics research on tyrosine kinase inhibitors in metastatic renal cell cancer: a systematic review

Expert Review of Molecular Diagnostics
Meta H M DiekstraHenk-Jan Guchelaar

Abstract

The individual response to targeted tyrosine kinase inhibitors (TKIs) in the treatment of metastatic renal cell cancer (mRCC) is highly variable. Outlined in this article are findings on potential biomarkers for TKI treatment outcome in mRCC and an evaluation of the status of clinical implementation. Articles were selected by two independent reviewers using a systematic search in five medical databases on renal cell carcinoma, TKIs, and pharmacogenetics. Many researchers have focused on predictive biomarkers for treatment outcome of targeted therapies in mRCC patients. Attempts to explain differences in efficacy and toxicity of TKIs by use of genetic variants in genes related to the pharmacokinetics and pharmacodynamics of the drug have been successful. Most findings on potential biomarkers have not been validated and therefore biomarker testing to guide choice of therapy and dose in mRCC is not yet feasible.

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Citations

Aug 23, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Daniela RodriguesMárcia Carvalho
Dec 6, 2016·International Journal of Molecular Sciences·Francesca PerrottiDamiana Pieragostino
Nov 8, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel J GeorgeAlain Ravaud
Sep 9, 2017·Pharmacology & Therapeutics·Megan Li, Deanna L Kroetz
Jun 9, 2021·Journal of Experimental & Clinical Cancer Research : CR·Revati SharmaNuzhat Ahmed
Jun 23, 2021·Aktuelle Urologie·Philip ZeuschnerKerstin Junker
Jun 1, 2018·Chemical Research in Toxicology·Gracia M AmayaKlarissa D Jackson

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