A decade's experience with an individualized clomiphene treatment regimen including its effect on the postcoital test

Fertility and Sterility
M GyslerE J Bailey


During a 10-year period, 428 women received clomiphene citrate according to a graduated therapeutic regimen in which the dose of clomiphene and the laboratory studies were individualized according to each patient's history, examination and response. Of the 428 patients, 85.3% ovulated and 42.8% conceived. The great majority of those who conceived did so during the first three ovulatory cycles. There was no evidence that clomiphene therapy was associated with the induction of another cause of infertility. Overall, 88.2% of those with no other causes for infertility who ovulated also conceived. However, only 7.8% of those who had one or more factors in addition to anovulation became pregnant. There was no evidence that clomiphene adversely affected the postcoital test, as only 15% of the patients had poor cervical mucus. The low rate of complications of this treatment, 5.1% cyst formation as well as the 14% abortion rate and the 2.6% congenital anomaly rate and the excellent gestational outcome in those who conceived support the use of this treatment regimen.


May 12, 2004·Fertility and Sterility·Amin Rostami-HodjeganW L Ledger
Sep 15, 2004·Fertility and Sterility·Practice Committee of the American Society for Reproductive Medicine
Jan 16, 1995·The American Journal of Medicine·M Gibson
Nov 11, 2003·Fertility and Sterility·Practice Committee of the American Society for Reproductive Medicine
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·B J Vollenhoven, D L Healy
May 22, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·G David Adamson, Valerie L Baker
Jan 11, 2000·Clinical Obstetrics and Gynecology·L J Wolf
Nov 18, 2003·Reproductive Biology and Endocrinology : RB&E·Roy Homburg
Oct 6, 2005·Reproductive Biology and Endocrinology : RB&E·Mohamed F M MitwallyMichael P Diamond
Jun 23, 2011·Reproductive Biology and Endocrinology : RB&E·Mohan S Kamath, Korula George
Jun 30, 2009·Journal of Human Reproductive Sciences·Lavanya RajashekarMadhuri Patil
Jan 1, 1989·Journal of Endocrinological Investigation·Z ShohamB Lunenfeld
Mar 7, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sefa KelekciEmine Demirel
Jan 1, 1990·Acta Obstetricia Et Gynecologica Scandinavica·E KokiaZ Ben-Rafael
Jan 1, 1996·Obstetrical & Gynecological Survey·V L Baker, R B Jaffe
Jan 1, 1988·Acta Obstetricia Et Gynecologica Scandinavica·R TepperJ Blankstein
Jul 16, 2003·The Nurse Practitioner·Kathryn M Hill
Feb 11, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Hatem Abu HashimIbrahim Abd Elaal
May 26, 2018·Obstetrics and Gynecology·American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Feb 28, 2003·Expert Opinion on Investigational Drugs·Mohamed F M Mitwally, Robert F Casper
Apr 9, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·T GiannopoulosCarolyn Croucher
May 10, 2005·Human Reproduction·Roy Homburg
Mar 6, 2008·Human Fertility : Journal of the British Fertility Society·Roy Homburg
Jul 21, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hatem Abu HashimIbrahim Abd Elaal
Jan 21, 2016·The Journal of Obstetrics and Gynaecology Research·Amr M Salaheldin AbdelHamidWael A Ismail Madkour
May 13, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Pierluigi GiampaolinoGiuseppe Bifulco
May 29, 2002·Current Opinion in Obstetrics & Gynecology·Mohamed F M Mitwally, Robert F Casper
Nov 5, 2003·Expert Opinion on Pharmacotherapy·Roy Homburg
Apr 23, 2005·Human Reproduction·Anne Z SteinerRichard J Paulson
Sep 8, 2004·Journal of the Society for Gynecologic Investigation·Mohamed F M Mitwally, Robert F Casper
Jul 12, 2005·Current Medical Research and Opinion·Karen E Elkind-HirschDan Gipe
Jul 12, 2005·Human Reproduction·Ioannis E Messinis
Oct 10, 2001·Human Fertility : Journal of the British Fertility Society·S Nasseri, W L Ledger
Sep 21, 2006·The Journal of Obstetrics and Gynaecology Research·Mosammat R BegumMomtaz Begum
Apr 25, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·R K Bhathena
Jan 8, 2005·Journal of Endocrinological Investigation·S PalombaF Zullo
May 12, 2010·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·C CoughlanM Wingfield
Jan 1, 2021·Expert Review of Endocrinology & Metabolism·Georgios PapadakisMelpomeni Peppa
Dec 22, 2020·Clinical Obstetrics and Gynecology·Samantha Kodama, Saioa Torrealday
Apr 16, 2013·Fertility and Sterility·Marleen J NahuisFulco van der Veen

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.