PMID: 9420261Jan 7, 1998Paper

A defective interference-like phenomenon of human hepatitis B virus in chronic carriers

Journal of Virology
T T YuanC Shih

Abstract

Defective interfering (DI) particles have been found in many RNA and DNA viruses of bacteria, plants, and animals since their first discovery in influenza virus. However, this fundamental phenomenon has not been demonstrated in human natural infections. Using a new approach, here we provide the first experimental evidence for the existence of DI-like viruses in human chronic carriers of hepatitis B virus (HBV). Functional characterization of naturally occurring core internal deletion (CID) variants of HBV revealed all of the features of DI particles. When equal amounts of wild-type and CID variant DNAs were cotransfected into a human hepatoma cell line, Huh7, a three- to fivefold enrichment of CID variants was most often observed. The fluctuations of the virus populations between CID variants and helper HBV in three chronic carriers are reminiscent of the cycling phenomenon in other DI viral systems. This finding has important implications for chronic viral hepatitis and other chronic progressive viral diseases.

References

Dec 1, 1991·The Journal of Clinical Investigation·T WakitaT Morishima
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C H ShihM H Ho
Oct 10, 1985·Nature·P TiollaisA Dejean
Oct 9, 1986·The New England Journal of Medicine·A M Haywood
Jan 1, 1986·Current Topics in Microbiology and Immunology·A D Barrett, N J Dimmock
Sep 10, 1966·Nature·J CrickF Brown
Jul 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M Doyle, J J Holland
Apr 25, 1970·Nature·A S Huang, D Baltimore
Jul 1, 1984·The Journal of General Virology·S PedleyU Desselberger
Jun 1, 1994·Digestive Diseases and Sciences·T T AyeM Mizokami
Jul 1, 1995·The Journal of General Virology·U S Akarca, A S Lok

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Citations

Sep 10, 1999·Reviews in Medical Virology·S L NguiC G Teo
Mar 24, 2005·World Journal of Gastroenterology : WJG·Jaw-Ching WuWan-Jr Syu
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Petra PreikschatHelga Meisel
Apr 23, 2002·Journal of Virology·Adam ZlotnickJennifer M Johnson
Oct 7, 2008·World Journal of Gastroenterology : WJG·Tao ShenHong Dong
Jun 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y H NiH L Chen
Jul 25, 2009·Journal of Medical Virology·Fen JiChangqing Zeng
Dec 6, 2008·Reviews in Medical Virology·Yu-Mei Wen, Yong-Xiang Wang

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