PMID: 11904592Mar 21, 2002Paper

A deficiency in interferon-alpha production in women with vulvar vestibulitis

American Journal of Obstetrics and Gynecology
Stefan GerberSteven S Witkin

Abstract

Previous studies have suggested that interferon-alpha may be an effective treatment for some women with vulvar vestibulitis. We evaluated whether women with this syndrome had a deficiency in endogenous and induced interferon-alpha production. Blood was collected in heparinized tubes from 62 women with vulvar vestibulitis and 47 control women of similar age and ethnicity. Whole blood cultures were incubated in the presence of 0.1 ng/mL lipopolysaccharide (induced) or culture medium (uninduced) for 18 to 20 hours. Aliquots were tested for interferon-alpha levels by enzyme-linked immunosorbent assay. Vestibular samples were tested for human papillomavirus by polymerase chain reaction. Aliquots were also characterized for alleles of the polymorphic gene, interleukin-1 receptor antagonist, by polymerase chain reaction. In uninduced cultures, interferon-gamma was present in 68.1% of control subjects as opposed to 33.9% of vulvar vestibulitis patients ( P =.0005). Similarly, after lipopolysaccharide stimulation, 70.2% of control subjects and only 48.4% of patients produced interferon-alpha ( P =.03). Among the positive samples, however, there were no differences in the interferon-alpha levels between patients and control subjects. In ...Continue Reading

References

Jan 1, 1988·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R E PykaB P Croker
Mar 1, 1989·Obstetrics and Gynecology·B J Horowitz
Apr 1, 1986·American Journal of Obstetrics and Gynecology·B M PeckhamG R Hafez
Mar 1, 1997·The Clinical Journal of Pain·S BergeronK Pagidas
Feb 25, 1998·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·S ChadhaW I van der Meijden
Jan 5, 2000·Sexually Transmitted Infections·A V SarmaJ D Sobel
Feb 29, 2000·American Journal of Obstetrics and Gynecology·J JeremiasS S Witkin
Jan 1, 1996·Infectious Diseases in Obstetrics and Gynecology·W J LedgerS S Witkin

❮ Previous
Next ❯

Citations

Mar 14, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Massimo Amadori
Oct 19, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Elisabetta RazzuoliMassimo Amadori
May 25, 2011·Obstetrics and Gynecology·Catherine M LeclairTerry K Morgan
Jul 22, 2014·Journal of Women's Health·Maheruh KhandkerBernard L Harlow
Oct 7, 2004·American Journal of Obstetrics and Gynecology·Oksana BabulaSteven S Witkin
Mar 26, 2004·American Journal of Obstetrics and Gynecology·Oksana BabulaSteven S Witkin
Sep 19, 2002·American Journal of Obstetrics and Gynecology·Steven S WitkinWilliam J Ledger
Dec 3, 2014·American Journal of Obstetrics and Gynecology·Päivi TommolaSeppo Meri
Nov 3, 2009·Behaviour Research and Therapy·Geneviève DesrochersMélanie Jodoin
Mar 24, 2018·Journal of Lower Genital Tract Disease·Barbara D ReedDaniel G Remick
Nov 18, 2016·F1000Research·Ahinoam Lev-Sagie, Steven S Witkin
May 25, 2006·Obstetrical & Gynecological Survey·Denniz ZolnounJohn Steege
Sep 28, 2010·Dermatologic Therapy·Claire S Danby, Lynette J Margesson
Oct 29, 2002·Current Opinion in Obstetrics & Gynecology·Elizabeth Gunther Stewart
May 5, 2005·Journal of Lower Genital Tract Disease·Hope K HaefnerEdward J Wilkinson
Jul 12, 2016·Obstetrics and Gynecology·K Jane ChalmersG Lorimer Moseley
Apr 21, 2005·American Journal of Epidemiology·Bernard L Harlow, Elizabeth Gunther Stewart
May 19, 2012·Journal of Midwifery & Women's Health·Kim J Cox, Cynthia E Neville
Jun 8, 2011·Scandinavian Journal of Immunology·E RazzuoliM Amadori
Oct 27, 2006·Current Infectious Disease Reports·Carolyn Gardella
Sep 7, 2012·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Gary Ventolini
Jan 13, 2015·Pain Practice : the Official Journal of World Institute of Pain·Jose De AndresAna Minguez
Feb 6, 2007·Lancet·Rosemary Basson, Willibrord Weijmar Schultz
Oct 5, 2010·Dermatologic Clinics·Vlada Groysman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Reproductive Medicine
Glenn GauntC Robert Stanhope
The Journal of Reproductive Medicine
Alexander GreensteinLiora Abramov
American Journal of Obstetrics and Gynecology
Adam C SteinbergKristene E Whitmore
Obstetrics and Gynecology
Maaike A F TraasMark E Vierhout
© 2022 Meta ULC. All rights reserved