A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus

Epilepsia
Eugen TrinkaDaniel H Lowenstein

Abstract

The Commission on Classification and Terminology and the Commission on Epidemiology of the International League Against Epilepsy (ILAE) have charged a Task Force to revise concepts, definition, and classification of status epilepticus (SE). The proposed new definition of SE is as follows: Status epilepticus is a condition resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms, which lead to abnormally, prolonged seizures (after time point t1 ). It is a condition, which can have long-term consequences (after time point t2 ), including neuronal death, neuronal injury, and alteration of neuronal networks, depending on the type and duration of seizures. This definition is conceptual, with two operational dimensions: the first is the length of the seizure and the time point (t1 ) beyond which the seizure should be regarded as "continuous seizure activity." The second time point (t2 ) is the time of ongoing seizure activity after which there is a risk of long-term consequences. In the case of convulsive (tonic-clonic) SE, both time points (t1 at 5 min and t2 at 30 min) are based on animal experiments and clinical research. This evidence is incomplete, and there is ...Continue Reading

References

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Citations

Aug 28, 2015·Expert Review of Neurotherapeutics·Annamaria VezzaniAndrea O Rossetti
Dec 3, 2015·Expert Opinion on Pharmacotherapy·Eugen TrinkaFrancesco Brigo
Feb 24, 2016·Epilepsy Currents·Cynthia L Harden
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Nov 26, 2015·Journal of Pain and Symptom Management·Constanze RémiBerend Feddersen
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May 9, 2016·Seizure : the Journal of the British Epilepsy Association·Amélia Mendes, Luísa Sampaio
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