A definition of the Mycobacterium avium complex for taxonomical and clinical purposes, a review

International Journal of Systematic and Evolutionary Microbiology
Jakko van IngenBarbara A Brown-Elliott

Abstract

Nontuberculous mycobacteria, particularly the Mycobacterium avium complex (MAC) bacteria, are increasingly recognized as opportunistic pathogens of humans. As a result, studies on antibiotic treatment and taxonomy of the MAC are intensifying, but an updated definition of what constitutes the MAC, either for taxonomical studies or for clinical purposes, is lacking. On the basis of literature review and phylogenetic analyses, we propose to define the MAC as a grouping of slow-growing mycobacteria that show corresponding values in at least two of the following targets against either M. avium ATCC 25291T or Mycobacterium intracellulare ATCC 13950T: >99.4 % sequence identity for the full 16S rRNA gene, >98.7 % for the partial (5') 16S rRNA gene, >97.3 % for hsp65 and >94.4 % for rpoB region V. A >97.5 % value in concatenated analyses of >2500 bp that includes 16S rRNA, hsp65 and rpoB gene sequence data or ≥85 % average nucleotide identity to M. avium ATCC 25291T or M. intracellulare ATCC 13950T on basis of whole genome sequencing data is recommended. This molecular definition is based on the distances observed between the classical members of the MAC, M. avium and M. intracellulare. Applying this definition, the complex currently co...Continue Reading

References

Jan 1, 1979·The American Review of Respiratory Disease·E Wolinsky
May 1, 1993·Journal of Bacteriology·R Frothingham, K H Wilson
Jan 1, 1959·The Medical Clinics of North America·E H RUNYON
Jul 29, 2004·International Journal of Systematic and Evolutionary Microbiology·Enrico TortoliClaudio Scarparo
Jan 18, 2005·International Journal of Systematic and Evolutionary Microbiology·G DevulderJ P Flandrois
Feb 4, 2006·Journal of Clinical Microbiology·Christine Y TurenneMarcel A Behr
Sep 8, 2006·International Journal of Systematic and Evolutionary Microbiology·Martha I MurciaMaria J Garcia
Feb 6, 2007·American Journal of Respiratory and Critical Care Medicine·David E GriffithUNKNOWN Infectious Disease Society of America
Apr 13, 2007·Clinical Microbiology Reviews·Christine Y TurenneMarcel A Behr
Sep 2, 2008·Emerging Infectious Diseases·Birgitta SchweickertAnnette Moter
Oct 10, 2008·International Journal of Systematic and Evolutionary Microbiology·Didi BangVibeke Ostergaard Thomsen
Dec 3, 2008·Microbiology·Iskandar Ben SalahMichel Drancourt
Apr 24, 2009·Journal of Clinical Microbiology·Enrico TortoliMichela Pascarella
Jul 22, 2009·International Journal of Systematic and Evolutionary Microbiology·J van IngenD van Soolingen
Jul 25, 2009·International Journal of Systematic and Evolutionary Microbiology·Jakko van IngenDick van Soolingen
Jul 25, 2009·International Journal of Systematic and Evolutionary Microbiology·Iskandar Ben SalahMichel Drancourt
Nov 13, 2009·Journal of Clinical Microbiology·Enrico TortoliAnna Fabio
Jun 21, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Enrico Tortoli
Mar 20, 2012·International Journal of Systematic and Evolutionary Microbiology·Byoung-Jun KimBum-Joon Kim
Jun 16, 2012·Journal of Medical Microbiology·J van IngenD van Soolingen
Nov 12, 2013·Emerging Infectious Diseases·Enrico TortoliGian Maria Rossolini
May 9, 2014·Journal of Clinical Microbiology·Rina de ZwaanDick van Soolingen
Dec 3, 2014·Diagnostic Microbiology and Infectious Disease·Daniel P BoyleChao Qi
Jun 2, 2015·American Journal of Respiratory and Critical Care Medicine·David E GriffithRichard J Wallace
Oct 6, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kazuya IchikawaTetsuya Yagi
Mar 24, 2016·Molecular Biology and Evolution·Sudhir KumarKoichiro Tamura
May 18, 2016·International Journal of Systematic and Evolutionary Microbiology·So-Young LeeBum-Joon Kim
May 16, 2017·Journal of Medical Microbiology·Arthur B PranadaMarkus Timke
Oct 17, 2017·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Enrico TortoliDaniela M Cirillo
Nov 28, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F AlcaideUNKNOWN European Study Group on Genomics and Molecular Diagnosis (ESGMD)

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Citations

Oct 27, 2018·American Journal of Respiratory and Critical Care Medicine·Charles L Daley, Kenneth N Olivier
Sep 13, 2019·International Journal of Mycobacteriology·Eduarda PenaSofia Jordão
Jun 18, 2020·International Journal of Molecular Sciences·Laura Rindi
Jul 7, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Charles L DaleyKevin L Winthrop
Feb 23, 2019·Emerging Infectious Diseases·Nabeeh A HasanMichael Strong
Jul 13, 2019·The European Respiratory Journal·Enrico TortoliJakko van Ingen
Oct 19, 2019·The Journal of Antibiotics·Melissa MenichiniLaura Rindi
Jun 22, 2019·The European Respiratory Journal·Steven CowmanMichael R Loebinger
Feb 6, 2020·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Carlos D Sánchez-CárdenasRigoberto Hernández-Castro
Nov 3, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicholas A TurnerJason E Stout
Jan 16, 2021·Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews·Takashi HiraseShari R Liberman
Jun 5, 2019·Journal of Comparative Pathology·K J VailD J Wiener
Apr 13, 2021·Current Clinical Microbiology Reports·Giovanni Ghielmetti, Urs Giger
Feb 10, 2021·Antimicrobial Agents and Chemotherapy·Uday S GanapathyThomas Dick
Jun 3, 2021·Infectious Disease Reports·Sanu RajendraprasadDavid Quimby
Jul 15, 2021·Seminars in Respiratory and Critical Care Medicine·Shera Tan, Shannon Kasperbauer
Jul 23, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·James D ChalmersJean-Louis Herrmann
Oct 5, 2021·Antimicrobial Agents and Chemotherapy·Uday S GanapathyThomas Dick

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