A 'degradable' poly(vinyl alcohol) iron oxide nanoparticle hydrogel

Acta Biomaterialia
A Dawn BannermanWankei Wan

Abstract

Polymeric materials that contain magnetic nanoparticles are extremely useful in many applications including as multifunctional drug carriers, imaging contrast agents, or scaffold material. There is a need for biomaterials with appropriate chemical, mechanical, and magnetic properties that also have the ability to degrade or dissolve over time so they can be eliminated from the body following use. In this work, we explore the use of iron oxide nanoparticle (IONP) formation in poly(vinyl alcohol) (PVA) as a crosslinking method in conjunction with physical crosslinking achieved using low temperature thermal cycling (LTTC). PVA-IONP hydrogels were fabricated and characterized. IONPs contribute to the crosslinking of the PVA-IONP material, and their subsequent removal reduces crosslinking, and therefore stability, of the material, allowing dissolution to occur. Dissolution studies were performed on PVA-IONP hydrogels and dissolution was compared for films in solutions of varying pH, in the presence of iron chelating agents, and in simulated physiological and tumor conditions in cell culture media. Iron release, mass loss, and mechanical testing data was collected. This work demonstrates the ability of this biomaterial to 'degrade' o...Continue Reading

References

Oct 1, 1990·The Biochemical Journal·K Thorstensen, I Romslo
Jan 19, 2000·Molecular Medicine Today·M StubbsC L Bashford
Mar 8, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C M HassanN A Peppas
May 9, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·L E Millon, W K Wan
Apr 11, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Leonardo E MillonWankei Wan
Oct 15, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Leonardo E MillonWankei Wan
Sep 6, 2013·Cancer Cell International·Yasumasa KatoYuh Baba
May 26, 2016·Expert Opinion on Drug Delivery·Dawn Bannerman, Wankei Wan

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Citations

Sep 6, 2018·Pharmaceutics·Sérgio R S VelosoElisabete M S Castanheira
Jan 30, 2018·Frontiers in Pharmacology·Mariana H RemiãoTiago Collares
Mar 27, 2020·Frontiers in Chemistry·Zhongyang LiuPeifu Tang
Aug 7, 2021·Macromolecular Bioscience·Wenzhen DuPeng Zhang
Oct 30, 2018·The Journal of Physical Chemistry. B·C J MollH J Bakker
Jul 3, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ke-Han ShenYi-Cheun Yeh

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