A dehydrogenative cross-coupling reaction between aromatic aldehydes or ketones and dialkyl H-phosphonates for formyl or acylphenylphosphonates

Organic & Biomolecular Chemistry
Xing-Fen HuangZhi-Zhen Huang

Abstract

A novel DCC reaction between aromatic aldehydes or ketones and H-phosphonates has been developed for the synthesis of p-formyl or p-acylphenylphosphonates. The synthetic method has excellent para regioselectivities, good yields, and broad substrate scopes and is more benign to the environment. The DCC reaction also tolerates many functional groups, and results in a series of new p-formyl and p-acylphenylphosphonates, which should be important building blocks for the synthesis of versatile arylphosphonate derivatives.

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Citations

Jul 2, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Tieqiao ChenLi-Biao Han
Mar 28, 2017·Chemistry : a European Journal·Rizwan S ShaikhBurkhard König
Jan 11, 2020·Organic Letters·Jie WangYingsheng Zhao

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