A deletion in the chemokine receptor 5 (CCR5) gene is associated with tickborne encephalitis

The Journal of Infectious Diseases
Elin KindbergLennart Svensson

Abstract

Tickborne encephalitis (TBE) virus infections can be asymptomatic or cause moderate to severe injuries of the central nervous system. Why some individuals develop severe disease is unknown, but a role for host genetic factors has been suggested. To investigate whether chemokine receptor CCR5 is associated with TBE, CCR5Delta32 genotyping was performed among Lithuanian patients with TBE (n=129) or with aseptic meningoencephalitis (n=76) as well as among control subjects (n=134). We found individuals homozygous for CCR5Delta32 (P= .026) only among patients with TBE and a higher allele prevalence among patients with TBE compared with the other groups studied. CCR5Delta32 allele prevalence also increased with the clinical severity of disease.

References

Aug 31, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Aukse MickieneLars Lindquist
Dec 24, 2002·Seminars in Immunology·Mark M Wong, Eleanor N Fish
Mar 5, 2003·Antiviral Research·T S GritsunE A Gould
Mar 12, 2003·Vaccine·Mats Haglund, Göran Günther
Mar 12, 2003·Vaccine·Heidemarie Holzmann
Jun 12, 2003·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Gérard Lucotte
Jun 28, 2005·Journal of Neuropathology and Experimental Neurology·Ellen GelpiHerbert Budka
Oct 19, 2005·The Journal of Experimental Medicine·William G GlassPhilip M Murphy
Jan 19, 2006·The Journal of Experimental Medicine·William G GlassPhilip M Murphy

❮ Previous
Next ❯

Citations

Oct 9, 2008·Immunologic Research·Shelly J RobertsonMarshall E Bloom
May 2, 2012·Immunologic Research·Susana V Bardina, Jean K Lim
Sep 6, 2008·The Journal of Infectious Diseases·Jeffrey M JacobsonWilliam C Olson
Feb 5, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Athe M N TsibrisDaniel R Kuritzkes
Dec 23, 2009·The Journal of Infectious Diseases·Sunil K Ahuja, Weijing He
Sep 11, 2012·AIDS Research and Human Retroviruses·Katarzyna ZwolińskaEgbert Piasecki
Feb 4, 2011·The Journal of Infectious Diseases·Yoav KeynanKeith R Fowke
Jan 11, 2011·The Journal of Infectious Diseases·Elin KindbergLennart Svensson
Apr 3, 2009·Current Opinion in HIV and AIDS·William C Olson, Jeffrey M Jacobson
Feb 16, 2012·The Pediatric Infectious Disease Journal·Mona-Lisa EngmanMikael Sundin
Sep 3, 2009·AIDS·Pierre Corbeau, Jacques Reynes
Jun 24, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Julie B DumondAngela D M Kashuba
Feb 10, 2011·Journal of Translational Medicine·Bruce L GilliamRobert R Redfield
Sep 30, 2010·Emerging Infectious Diseases·Yoav KeynanKeith R Fowke
Mar 13, 2014·Microbes and Infection·Brian BrestovacDavid Williams
Apr 20, 2014·Respiratory Research·Paul StollMarek Lommatzsch
Apr 20, 2012·Expert Review of Anti-infective Therapy·José R Blanco, Laura Ochoa-Callejero
Jul 23, 2009·Expert Review of Anti-infective Therapy·Shilpa Sayana, Homayoon Khanlou
Oct 14, 2008·Expert Opinion on Biological Therapy·Anna H Roukens, Leo G Visser
May 1, 2015·Expert Opinion on Drug Discovery·Nevena VeljkovicMarco Radi
Jan 20, 2016·Nature Reviews. Neurology·Guillaume Martin-BlondelRoland S Liblau
Feb 26, 2016·Journal of Neuroinflammation·Sambor GrygorczukSławomir Pancewicz
Jun 26, 2012·International Journal of Antimicrobial Agents·Guido Antonelli, Ombretta Turriziani
Jun 16, 2012·Immunology Letters·Marcello AllegrettiAmanda E I Proudfoot
Oct 26, 2010·Travel Medicine and Infectious Disease·Bastian DörrbeckerFrank T Hufert
Sep 17, 2013·Journal of Medical Virology·A S RosenbergP M Murphy
Jun 23, 2009·Journal of Travel Medicine·Gerd D BurchardJane Zuckerman
Jul 6, 2015·Current Opinion in Virology·Kristina Allers, Thomas Schneider
Nov 29, 2008·European Journal of Immunology·Shaza A FadelAndrew D Luster
Apr 9, 2008·Acta Paediatrica·Lars Lindquist
Nov 17, 2011·Reviews in Medical Virology·Gregorius J SipsJolanda M Smit
Apr 29, 2015·The Journal of General Virology·A FalconI Casas
Apr 14, 2016·Ticks and Tick-borne Diseases·Andrey V BarkhashAida G Romaschenko

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.