PMID: 8600566Nov 1, 1995Paper

A densely methylated DNA island is associated with a chromosomal replication origin in the human RPS14 locus

Somatic Cell and Molecular Genetics
E S Tasheva, D J Roufa

Abstract

We describe a 258-bp densely methylated DNA island (DMI) and chromosomal origin of bidirectional DNA replication within the transcribed portion of the human RPS14 intron 1. Together with the DMIs previously detected in two functional Chinese hamster replication origins [see Ref. 1, pp. 5636-5644], observations described in this report strengthen the correlation between densely methylated DNA islands and active mammalian chromosomal replication origins. Accordingly, DMIs may prove to be reliable physical markers for origins of bidirectional DNA replication in complex genomic DNAs of higher animals.

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Citations

Jun 10, 1998·Nucleic Acids Research·T ReinH Zorbas
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·B H RamsahoyeR Jaenisch
Nov 20, 2008·British Journal of Haematology·Azim Mohamedali, Ghulam J Mufti
Dec 29, 2004·Analytical Biochemistry·Antonella San RomerioAlberto Battezzati
Aug 28, 1999·The Journal of Biological Chemistry·T ReinM L DePamphilis
Apr 11, 1997·The Journal of Biological Chemistry·T ReinH Zorbas
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gregory P WhitePatrick G Holt

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