A depressed peripheral cellular immune response is related to symptomatic neurocysticercosis

Microbes and Infection
Anahí ChavarríaE Sciutto

Abstract

Human neurocysticercosis can cause mild or severe neurological symptoms or be completely asymptomatic. This heterogeneity may depend on host factors such as gender, age and immune-inflammatory response. The present study describes the specific peripheral immune response related to the different forms of neurocysticercosis in the adult population of both sexes. Asymptomatic cases (n = 26) mainly presented single calcified cysticerci in brain parenchyma or in the subarachnoid space of the sulci with a predominantly TH2 response (IL-4, IL-5, IL-13), high levels of IL-12 in supernatants of specifically stimulated peripheral blood mononuclear cells, and low plasma levels of all specific IgG subclasses. Symptomatic patients (n = 26) constituted a heterogeneous group, and had single or multiple cysticerci in vesicular, colloidal, calcified or mixed stages. This group showed parasites located in the subarachnoid space of the base and/or in the sulci, in the ventricular cavities, in parenchyma or in mixed locations. Symptomatic patients showed a depressed specific cellular immune response and increased levels of all specific IgG subclasses. This evidence supports the existence of two clear different immune profiles according to neurocys...Continue Reading

References

Sep 3, 1992·The New England Journal of Medicine·P M SchantzA Flisser
Jan 1, 1994·The Journal of Experimental Medicine·K J ElseR K Grencis
Jan 1, 1994·Medicine·W X ShanderaR Armstrong
Sep 6, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V RodriguesJ O Marquez
Feb 6, 2002·Springer Seminars in Immunopathology·R H Zubler
Jun 5, 2003·Parasitology Research·Sergio López-BrionesEdda Sciutto
Jul 13, 2004·Autoimmunity Reviews·A Chavarria, J Alcocer-Varela
Jun 7, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Anahí ChavarríaEdda Sciutto

❮ Previous
Next ❯

Citations

Jun 24, 2011·Medical Microbiology and Immunology·Brenda SáenzEdda Sciutto
Mar 3, 2010·Parasitology Research·Vasudevan PrabhakaranAnna Oommen
Sep 24, 2008·Neurocritical Care·Chad M Miller, Paul M Vespa
Feb 12, 2009·Journal of Biosciences·Kashi Nath PrasadAloukick Kumar Singh
Feb 2, 2010·Transactions of the Royal Society of Tropical Medicine and Hygiene·Agnès FleuryCarlos Larralde
Aug 31, 2012·The Neurologist·Graciela CárdenasJosé Luis Soto-Hernández
Jun 25, 2014·Medical Microbiology and Immunology·Graciela CárdenasAgnes Fleury
Sep 24, 2015·Clinical and Experimental Immunology·Asiel Arce-SillasLaura Adalid-Peralta
Feb 15, 2008·Diagnostic Microbiology and Infectious Disease·Amit PrasadMazhar Husain
Dec 17, 2015·Parasite Immunology·A FleuryE Sciutto
Dec 3, 2015·Parasitology·Vania B L MouraRuy S Lino
Nov 29, 2007·Parasite Immunology·E SciuttoC Larralde
Jun 26, 2014·Parasite Immunology·H H GarciaUNKNOWN Cysticercosis Working Group in Peru
Jun 14, 2013·Clinical & Developmental Immunology·Laura Adalid-PeraltaEdda Sciutto
Oct 28, 2015·PLoS Neglected Tropical Diseases·Iskra TueroUNKNOWN Cysticercosis Working Group in Perú
Mar 17, 2015·PLoS Neglected Tropical Diseases·Siddhartha MahantyUNKNOWN Cysticercosis Working Group in Peru
Dec 15, 2015·PLoS Neglected Tropical Diseases·Carla CangalayaUNKNOWN Cysticercosis Working Group in Peru
Mar 15, 2019·PLoS Neglected Tropical Diseases·Sandra PalmaUNKNOWN Cysticercosis Working Group in Peru
Sep 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jasim UddinJon S Friedland
Dec 22, 2010·Expert Review of Anti-infective Therapy·Agnès FleuryTeresa Corona
Apr 28, 2021·PLoS Neglected Tropical Diseases·Rogger P Carmen-OrozcoUNKNOWN Cysticercosis Working Group in Peru

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis