A Description of Risk Factors for Non-alcoholic Fatty Liver Disease in the Southern Community Cohort Study: A Nested Case-Control Study.

Frontiers in Nutrition
Sudipa SarkarAdriana M Hung

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is associated with obesity and hypercholesterolemia. In addition, total fat and folate intake have been associated with NAFLD. Aims: We investigated risk factors for NAFLD among individuals of largely low socioeconomic status, and whether these associations differed by race. Methods: A nested case-control study was conducted within the Southern Community Cohort Study. Through linkage of the cohort with Centers for Medicare and Medicaid Services, International Classification of Diseases, Ninth Revision, Clinical Modification codes were used to identify incident NAFLD cases. Controls were matched 4:1 to cases on enrollment age, sex, and race. A logistic regression was used to estimate odds ratios for the associations of NAFLD with covariates of interest. Results: Neither total fat nor folate intake was significantly associated with NAFLD. Hypercholesterolemia (odds ratio 1.21) and body mass index (75th vs. 25th percentile) for blacks (odds ratio 1.96) and whites (odds ratio 2.33) were associated with an increased risk of non-alcoholic fatty liver disease. No significant interaction with race for any of the studied variables was noted. Conclusions: Both hypercholesterolemia and...Continue Reading

References

Apr 1, 1997·The American Journal of Clinical Nutrition·W C WillettL H Kushi
Sep 19, 2000·Medicine and Science in Sports and Exercise·B E AinsworthA S Leon
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
Feb 23, 2005·Nutrition·Sandra HirschMaría Pía de la Maza
Aug 1, 2006·Journal of Pediatric Gastroenterology and Nutrition·Marie-Laure FrelutGeneviève Potier de Courcy
May 6, 2008·International Journal of Epidemiology·Jennifer Beam Dowd, Allison E Aiello
Dec 24, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard GuerreroJeffrey D Browning
Feb 23, 2010·Journal of Health Care for the Poor and Underserved·Lisa B SignorelloWilliam J Blot
May 13, 2010·Digestive Diseases·Stefano BellentaniGiorgio Bedogni
Mar 29, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zobair M YounossiManirath Srishord
Aug 2, 2011·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Mustafa KoplayFuat Ozkan
Sep 3, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Jiankang LiuHerman A Taylor
Aug 4, 2012·International Journal of Food Sciences and Nutrition·Joan A Vaccaro, Fatma G Huffman
Aug 9, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Volodymyr TryndyakIgor P Pogribny
Nov 1, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J C K Wells
Nov 14, 2012·Therapeutic Advances in Endocrinology and Metabolism·Romina LomonacoKenneth Cusi
Sep 26, 2013·Nature Reviews. Gastroenterology & Hepatology·Quentin M Anstee, Christopher P Day
May 29, 2015·Digestive Diseases and Sciences·Jin-Zhou ZhuYou-Ming Li
Aug 15, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiSharon Hunt
Aug 25, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J N KiageE K Kabagambe
Jan 23, 2016·Journal of Clinical Biochemistry and Nutrition·Yining DaiYouming Li
Sep 15, 2016·International Journal of Preventive Medicine·Hamid ZolfaghariGity Sotoudeh

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Citations

Oct 12, 2020·Current Cardiology Reports·Jessica A Regan, Svati H Shah

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Methods Mentioned

BETA
coronary artery bypass
biopsies

Software Mentioned

R

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