PMID: 2118016Sep 1, 1990Paper

A detailed study of the effects of in vitro interferon treatment on the growth of two variants of the B16 mouse melanoma in the lungs: evidence for non-specific effects

Clinical & Experimental Metastasis
M BlackmoreG A Turner

Abstract

Interferon treatment increases the ability of tumour cells to colonize the lungs. Although it has been suggested that this effect can be explained by increases in the expression of MHC molecules the precise mechanism is still uncertain. The growth in the lungs of a low (F1) and a high colonizing variant (BL6) of the B16 mouse melanoma have been studied after in vitro treatment with interferon. Interferon-gamma, but not interferon-alpha/beta, increased the number of lung colonies formed after intravenous injection, but not after subcutaneous administration. Treatment also increased the sizes of the lung colonies formed and the number of radiolabelled cells retained by the lungs. However, no clear relationship was observed between the number of colonies formed and the concentration of interferon used. The effect of interferon on F1 was greater than on BL6, but the overall number of colonies formed was very similar. These results suggest that interferon increases the adhesiveness of these cell lines in a fairly non-specific manner, that seems unlikely to involve MHC molecules. As a results of this and other studies the importance of interferon in the process of tumour spread seems very questionable.

References

Oct 27, 1978·Biochimica Et Biophysica Acta·I Gresser, M G Tovey
Jan 1, 1985·Pharmacology & Therapeutics·P B Fisher, S Grant
Nov 15, 1987·International Journal of Cancer. Journal International Du Cancer·T J McMillanI R Hart
Oct 1, 1987·Clinical & Experimental Metastasis·P L LolliniP Nanni
Aug 14, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·S ThompsonG A Turner
Oct 15, 1985·International Journal of Cancer. Journal International Du Cancer·K TaniguchiG Klein
Jul 15, 1983·International Journal of Cancer. Journal International Du Cancer·L EisenbachM Feldman
Jan 1, 1983·Methods in Enzymology·J E Moen, S O Warnaar

❮ Previous
Next ❯

Citations

Oct 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·C M FleischmannW R Fleischmann
Nov 16, 2006·Applied Microbiology and Biotechnology·Kristof VranckenLieve Van Mellaert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.