PMID: 9445074Jan 28, 1998Paper

A determinant for central nervous system persistence localized in the capsid of Theiler's murine encephalomyelitis virus by using recombinant viruses

Journal of Virology
C AdamiH L Lipton

Abstract

The demyelinating process in Theiler's murine encephalomyelitis virus (TMEV) infection in mice requires virus persistence in the central nervous system. Using recombinant TMEV assembled between the virulent GDVII and less virulent BeAn virus cDNAs, we now provide additional evidence supporting the localization of a persistence determinant to the leader P1 (capsid) sequences. Further, recombinant viruses in which BeAn sequences progressively replaced those of GDVII within the capsid starting at the leader NH2 terminus suggest that a conformational determinant requiring homologous sequences in both the VP2 puff and VP1 loop regions, which are in close contact on the virion surface, might underlie persistence.

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M LuoH L Lipton
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R A GrantJ M Hogle
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M A CalenoffH L Lipton
Sep 1, 1990·Journal of Virology·A McAllisterM Brahic
May 1, 1994·Journal of Virology·N JarousseA McAllister
Jan 1, 1993·Methods in Enzymology·R M HortonL R Pease

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Citations

Jul 23, 2002·Journal of Virology·Honey V Reddi, Howard L Lipton
Sep 2, 2008·Emerging Infectious Diseases·Jan Felix DrexlerChristian Drosten
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·P E LobertT Michiels
Jan 17, 2004·Clinical Microbiology Reviews·Emilia L OleszakChris D Platsoucas
Oct 11, 2016·Reviews in Medical Virology·Shawn Zheng Kai TanMookkan Prabakaran
Jun 11, 1999·Journal of Virology·C MartinatM Brahic

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