A detrimental role of RelB in mature oligodendrocytes during experimental acute encephalomyelitis

Journal of Neuroinflammation
Angela S GuptaTomasz Kordula

Abstract

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). It is firmly established that overactivation of the p65 (RelA) nuclear factor kappa B (NF-κB) transcription factor upregulates expression of inflammatory mediators in both immune and non-immune resident CNS cells and promotes inflammation during MS. In contrast to p65, NF-κB family member RelB regulates immune cell development and can limit inflammation. Although RelB expression is induced during inflammation in the CNS, its role in MS remains unknown. To examine the role of RelB in non-immune CNS cells, we generated mice with RelB specifically deleted in astrocytes (RelBΔAST), oligodendrocytes (RelBΔOLIGO), or neural progenitor-derived cells (RelBΔNP). We used experimental autoimmune encephalomyelitis (EAE), an accepted mouse model of MS, to assess the effect of RelB deletion on disease outcomes and performed analysis on the histological, cellular, and molecular level. Despite being a negative regulator of inflammation, conditional knockout of RelB in non-immune resident CNS cells surprisingly decreased the severity of EAE. This protective effect was recapitulated by conditional deletion of RelB in oligodendrocytes but not astro...Continue Reading

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Citations

Mar 8, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christian EngelmannRonny Haenold
Apr 9, 2020·Frontiers in Immunology·Yifan ZhouWei Qiu
Jul 3, 2021·Cells·Karli MockenhauptTomasz Kordula
Oct 6, 2021·Scientific Reports·Guilhem LalleYenkel Grinberg-Bleyer

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