PMID: 3753904Jan 1, 1986Paper

A deuterium NMR study of labelled n-alkanol anesthetics in a model membrane

Chemistry and Physics of Lipids
J L ThewaltR J Cushley

Abstract

The 2H-NMR spectra of 50 wt.% aqueous multilamellar dispersions of dipalmitoylphosphatidylcholine (DPPC) containing either selectively deuterated 1-decanol (25 mol%) or [2H17]-1-octanol (25 mol%) have been measured as a function of temperature. Both alkanols are potent anesthetics. A detailed carbon-deuterium bond order parameter profile of 1-decanol in liquid crystalline phospholipid dispersions at 50 degrees C was determined from the quadrupolar splittings of 1-decanols deuterated at eight different positions. A maximum order parameter SCD = 0.20 was obtained for [5,5-2H2]-1-decanol, with labels at both ends of the 1-decanol exhibiting reduced order parameters. Explanations for the reduced order towards the hydroxyl group of 1-decanol are discussed in terms of either increased amplitudes of motion or geometric effects due to hydrogen bonding. By comparing the order parameter profile of sn-2 chain deuterated phosphatidylcholine dispersions containing 25 mol% 1-decanol (J.L. Thewalt, S.R. Wassall, H. Gorrissen and R.J. Cushley, Biochim. Biophys. Acta, 817 (1985) 355) with the profile of deuterated 1-decanol in DPPC, we estimate that decanol is approximately parallel to the C-3 to C-13 region of the phosphatidylcholine's sn-2 ch...Continue Reading

References

Aug 8, 1978·Biochemistry·J Seelig, N Waespe-Sarcevic
Jan 1, 1974·The Journal of Membrane Biology·J M Diamond, Y Katz

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Citations

Oct 6, 2007·Biochimica Et Biophysica Acta·Beate GriepernauRainer A Böckmann
Oct 4, 2006·Expert Opinion on Drug Metabolism & Toxicology·Anna Seelig, Grégori Gerebtzoff
Mar 22, 1988·Biochimica Et Biophysica Acta·P W WestermanD W Dubro
Apr 7, 1988·Biochimica Et Biophysica Acta·S R WassallW Stillwell
Oct 30, 2004·Molecular Membrane Biology·Andreas BootsveldCees W M Haest
Aug 5, 2006·Biophysical Chemistry·Ulf R PedersenPeter Westh
Jan 1, 1988·International Urology and Nephrology·A MarczyńskaM Augustyn
Dec 29, 2016·Proceedings of the National Academy of Sciences of the United States of America·Quoc Dat PhamEmma Sparr
Sep 20, 2020·Journal of Colloid and Interface Science·Viktoriia Meklesh, Patrick Kékicheff
Mar 1, 1991·Chemistry and Physics of Lipids·K Lohner

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