A developmental change in the content of parvalbumin in normal and dystrophic mouse (mdx) muscle

Journal of the Neurological Sciences
M SanoH Tsukagoshi

Abstract

A highly sensitive enzyme immunoassay for mouse parvalbumin was developed in this study. The amount of parvalbumin was determined by a sandwich enzyme immunoassay method using anti-parvalbumin IgG-coated polystyrene balls and an anti-parvalbumin Fab'-horseradish peroxidase conjugate. Parvalbumin could not be detected in normal and dystrophic skeletal muscles of newborn mice. In normal mice, it appeared in the first postnatal week and increased linearly thereafter until the 12th week in fast twitch muscle. Rapid increase in parvalbumin was seen during 3rd and 8th week. On the other hand, parvalbumin detected in the first postnatal week increased gradually, but did not yet reach the adult level at the 16th postnatal week in slow twitch muscle. In mdx mice, fast twitch muscles such as the gastrocnemius and tibialis anterior were found to contain significantly decreased amounts of parvalbumin, compared with those in control mice. In fast twitch muscle parvalbumin in mdx mice could not be detected in the newborn, increased until 4th week and thereafter did not increase as that in normal mice. In slow twitch muscle the postnatal increase in parvalbumin content was not different from that in control mice. These results suggest that th...Continue Reading

References

Dec 1, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·N C Kar, C M Pearson
Jul 1, 1978·Muscle & Nerve·N C Kar, C M Pearson
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Feb 1, 1985·Muscle & Nerve·M MüntenerC W Heizmann
Apr 1, 1986·The Biochemical Journal·E Leberer, D Pette
Aug 1, 1985·Endocrinology·T EndoT Onaya
Nov 1, 1984·Muscle & Nerve·J Dangain, G Vrbova
Jan 1, 1983·The International Journal of Biochemistry·K KatoT Nakajima
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C W HeizmannA M Rowlerson
Sep 1, 1981·Experimental Neurology·H G Parslow, D J Parry
Oct 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·I M WEINSTOCKA T MILHORAT

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Citations

Feb 1, 1993·Cell and Tissue Research·C AndressenM R Celio
Jan 1, 1995·Journal of Neurology·I Niebrój-Dobosz, M Lukasiuk
Sep 2, 1991·Biochimica Et Biophysica Acta·Y InagumaK Kato
Sep 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Marino DiFrancoJulio L Vergara
Oct 1, 2011·Journal of Applied Physiology·Jarrod A CallDawn A Lowe
Mar 9, 2004·The Journal of Physiology·Christopher E WoodsJulio L Vergara
Jul 28, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Nariaki FujimotoTohru Inoue
Oct 19, 2006·Acta histochemica·Uraporn VongvatcharanonSurapong Vongvatcharanon
Feb 17, 2009·Neuromuscular Disorders : NMD·Raffaella WillmannMarkus A Ruegg
Aug 15, 2002·American Journal of Physiology. Cell Physiology·Karl RougerJean J Leger

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