A developmental role for the heterotrimeric G protein Go alpha in a migratory population of embryonic neurons

Developmental Biology
A M HorganPhilip F Copenhaver

Abstract

The heterotrimeric G proteins are an extended family of guanyl nucleotide-binding proteins that serve essential functions in the mature nervous system but whose contributions to neuronal development remain poorly understood. We have investigated the potential role of one specific G protein, Go(alpha), in the control of neuronal migration. During embryogenesis of the moth, Manduca sexta, an identified population of undifferentiated neurons (the EP cells) migrate along sets of visceral muscle bands to form part of the enteric nervous system. Previously, immunohistochemical studies indicated the presence of Go(alpha)-related proteins in the EP cells during migration. We have now verified this result, using probes derived from the Go(alpha) gene in Manduca. A clone containing the full-length coding domain for Go(alpha) was sequenced from a Manduca cDNA library; digoxigenin-labeled probes were then made from this clone and used to examine the developmental expression of the Go(alpha) gene during embryogenesis. Go(alpha)-specific transcripts could first be detected in the EP cells several hours before the onset of their migration. The level of Go(alpha) expression in all of the EP cells continued to increase during migration, but sub...Continue Reading

Citations

May 3, 2002·European Journal of Biochemistry·Emmanuelle Jacquin-JolyRosario Maida
Jun 14, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jenna M RamakerPhilip F Copenhaver
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas M CoatePhilip F Copenhaver
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas M CoatePhilip F Copenhaver
Apr 24, 2007·Journal of Insect Physiology·J Joe HullShogo Matsumoto
Oct 16, 2004·Archives of Insect Biochemistry and Physiology·Peter J K Knight, Thomas A Grigliatti
Dec 3, 2010·Archives of Insect Biochemistry and Physiology·Gui-Juan KangCun-Gui Mao
Apr 11, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Philip F Copenhaver
Dec 10, 2016·Frontiers in Molecular Neuroscience·Jenna M RamakerPhilip F Copenhaver
Feb 16, 2017·Frontiers in Molecular Neuroscience·Philip F Copenhaver, Donat Kögel

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