A developmental study of the neural circuitry mediating motor inhibition in bipolar disorder.

The American Journal of Psychiatry
Judah WeathersEllen Leibenluft

Abstract

Despite increased interest in the developmental trajectory of the pathophysiology mediating bipolar disorder, few studies have compared adults and youths with bipolar disorder. Deficits in motor inhibition are thought to play an important role in the pathophysiology of the illness across the age spectrum. The authors compared the neural circuitry mediating this process in bipolar youths relative to bipolar adults and in healthy volunteers. Participants were pediatric (N=16) and adult (N=23) patients with bipolar disorder and healthy child (N=21) and adult (N=29) volunteers. Functional MRI (fMRI) data were acquired while participants performed the stop-signal task. During failed inhibition, an age group-by-diagnosis interaction manifested in the anterior cingulate cortex, with bipolar youths exhibiting hypoactivation relative to both healthy youths and bipolar adults, and bipolar adults exhibiting hyperactivation relative to healthy adults. During successful inhibition, a main effect of diagnosis emerged in the right nucleus accumbens and the left ventral prefrontal cortex, with bipolar patients in both age groups showing less activation than healthy subjects. Anterior cingulate cortex dysfunction during failed motor inhibition ...Continue Reading

Citations

Dec 19, 2012·Psychiatry Research·Roger B VarelaJoão Quevedo
Feb 5, 2014·Social Cognitive and Affective Neuroscience·Christen M DeveneyEllen Leibenluft
Aug 21, 2013·Psychiatry Research·Judah WeathersEllen Leibenluft
Aug 29, 2014·Bipolar Disorders·Frank P MacMasterMariko Sembo
May 29, 2014·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Argyris StringarisUNKNOWN Imagen Consortium
Nov 19, 2014·Frontiers in Psychiatry·Moon-Soo LeeMani N Pavuluri
Sep 13, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Charles Laidi, Josselin Houenou
Feb 17, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jace B KingMelissa P Lopez-Larson
Mar 10, 2019·Bipolar Disorders·Maria Kryza-LacombeJillian Lee Wiggins
Sep 1, 2019·Human Brain Mapping·Abraham C Van VoorhisScott R Sponheim
Mar 20, 2020·The Journal of Biological Chemistry·Rekha C BalachandranAaron B Bowman
Jun 22, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·João Ricardo SatoRodrigo Affonseca Bressan
Aug 3, 2021·Frontiers in Human Neuroscience·Huanhuan LiWenge Sun

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