A Diagnosis of Insomnia Is Associated With Differential Expression of Sleep-Regulating Genes in Military Personnel

Biological Research for Nursing
Jessica GillVincent Mysliwiec

Abstract

Sleep disturbance is a common and disturbing symptom in military personnel, with many individuals progressing to the development of insomnia, which is characterized by increased arousals, wakefulness after sleep onset, and distorted sleep architecture. The molecular mechanisms underlying insomnia remain elusive, limiting future therapeutic development to address this critical issue. We examined whole gene expression profiles associated with insomnia. We compared subjects with insomnia (n = 25) to controls (n = 13) without insomnia using microarray gene expression profiles obtained from peripheral samples of whole blood obtained from military personnel. Compared to controls, participants with insomnia had differential expression of 44 transcripts from 43 identified genes. Among the identified genes, urotensin 2 was downregulated by more than 6 times in insomnia participants, and the fold-change remained significant after controlling for depression, posttraumatic stress disorder, and medication use. Urotensin 2 is involved in regulation of orexin A and B activity and rapid eye movement during sleep. These findings suggest that differential expression of these sleep-regulating genes contributes to symptoms of insomnia and, specifi...Continue Reading

References

Jun 10, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Salvador Huitron-ResendizLuis de Lecea
Jan 16, 2007·Journal of the American College of Cardiology·David J Tester, Michael J Ackerman
Feb 1, 2008·The New England Journal of Medicine·Charles W HogeCarl A Castro
May 16, 2008·The New England Journal of Medicine·Michael S XydakisGerald A Grant
Jun 24, 2008·Neuroscience Letters·Tomoko OnoKazuyoshi Hirota
Sep 30, 2008·Nature Genetics·Taku MiyagawaKatsushi Tokunaga
Jun 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laurent SeugnetPaul J Shaw
Jan 7, 2010·The Journal of Head Trauma Rehabilitation·Eric B Larson, Felise S Zollman
Dec 2, 2010·Sleep·Nita Lewis MillerPanagiotis Matsangas
Mar 2, 2011·Sleep·Taku MiyagawaMakoto Honda
Sep 3, 2011·Sleep·David D LuxtonVincent Mysliwiec
Dec 20, 2011·Sleep Medicine·Fang HanEmmanuel Mignot
Dec 27, 2011·Neuron·Nicholas Stavropoulos, Michael W Young
May 29, 2012·BMC Family Practice·Matthew D MitchellCraig A Umscheid
Jul 4, 2012·Sleep·Karrie FitzpatrickFred W Turek
Aug 16, 2012·Hypertension·Julio Fernandez-MendozaEdward O Bixler
Sep 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Matthew E CarterLuis de Lecea
Oct 3, 2012·Archives of General Psychiatry·Victoria ShahlyRonald C Kessler
Feb 13, 2013·Continuum : Lifelong Learning in Neurology·Clifford B Saper
Feb 20, 2013·Sleep Medicine Reviews·Alexandros N VgontzasEdward O Bixler
Apr 6, 2013·PloS One·Cecilia U D StenforsLars-Göran Nilsson
Jun 12, 2013·Acta Physiologica·T Porkka-HeiskanenH-K Wigren
Aug 1, 2013·Nature and Science of Sleep·Michael A GrandnerSheila N Garland
Sep 10, 2013·Sleep Medicine Clinics·Jared Minkel, Andrew D Krystal
Oct 18, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Daniel S TyleeStephen J Glatt
Oct 16, 2014·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Vincent MysliwiecBernard J Roth

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Citations

Dec 22, 2016·Brain Sciences·Mackenzie J Lind, Philip R Gehrman
Oct 31, 2018·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Leorey N Saligan

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Methods Mentioned

BETA
phosphotransferase
1
ubiquitination

Software Mentioned

Partek Genomics Suite

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