A diagnostic review of carcinomas and sarcomas of the mediastinum: making the diagnosis on fine-needle aspiration and core needle biopsy specimens.

Seminars in Diagnostic Pathology
Alexander P SmithDerek B Allison

Abstract

The mediastinum is a complex anatomic region that can pose many diagnostic challenges on fine-needle aspiration (FNA) and core needle biopsy (CNB). With the recent technological advancements in EBUS-TBNA and EUS-guided procedures, FNA/CNB is being increasingly utilized to obtain the initial and, in many cases, the only diagnosis. As a result, it is imperative to have an understanding of the pearls and pitfalls associated with both the more common and rarer malignancies that occur at this site. Although the vast majority of mediastinal malignancies encountered in routine clinical practice are metastatic carcinomas to mediastinal lymph nodes, primary tumors and tumors that directly extend into the mediastinum are also encountered. As always, a multimodal approach with clinical and radiographic correlation, a targeted IHC panel, and molecular testing when indicated are indisposable and necessary tools in the diagnostic workup of mediastinal malignancies. This review focuses on the salient diagnostic features of malignancies of epithelial and mesenchymal origin, excluding tumors of neurogenic, thymic, hematolymphoid, and germ cell origins, which are discussed in separate articles of this issue.

References

Jan 11, 2003·Science·Michael C HeinrichJonathan A Fletcher
Dec 24, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David G PfisterUNKNOWN American Society of Clinical Oncology
Aug 17, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hong ZhangDani S Zander
Jan 11, 2005·Endocrine Pathology·Lori A EricksonRicardo V Lloyd
Jul 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans von der MaaseMichael Arning
Mar 29, 2006·Cancer·Janice N CormierMerrick I Ross
Jan 9, 2007·Current Opinion in Genetics & Development·Jonathan A Fletcher, Brian P Rubin
Jan 27, 2007·The American Journal of Surgical Pathology·Jefferson TerryTorsten O Nielsen
Mar 6, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Maria Fernanda C AmaryAdrienne M Flanagan
Mar 28, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Tae Jung KimMoon Soo Kim
Apr 10, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Valerie W RuschUNKNOWN Members of IASLC Staging Committee
Sep 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jonathan M SametCharles M Rudin
Apr 2, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisYasushi Yatabe
Jun 24, 2010·Applied Immunohistochemistry & Molecular Morphology : AIMM·Lisandro F LopesCarlos E Bacchi
Nov 4, 2010·Archives of Pathology & Laboratory Medicine·Hannah H Wong, Jun Wang
Jan 22, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisDavid Yankelewitz
May 17, 2011·American Journal of Clinical Pathology·Wai Chin FooJason L Hornick
Mar 6, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jamie KooDeepti Dhall
Jun 27, 2012·AJR. American Journal of Roentgenology·Christopher M WalkerMichael Lanuti
Nov 24, 2012·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·G NoussiosK Natsis
Jun 22, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Annikka WeissferdtCesar A Moran
Oct 15, 2013·Histopathology·Leona A Doyle, Jason L Hornick
Mar 15, 2014·The American Journal of Surgical Pathology·Akihiko YoshidaRyoji Kushima
Jan 23, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Laura L HoangLiang Cheng
Aug 1, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hui-Chun TaiHsuan-Ying Huang
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisUNKNOWN WHO Panel
Oct 5, 2016·Journal of the American Society of Cytopathology : JASC·Mohammed T LiloQing Kay Li
Dec 13, 2016·Journal of Thoracic Disease·Adnan M Al-Ayoubi, Raja M Flores
Jun 24, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer L SauterJennifer M Boland
Dec 12, 2017·Seminars in Diagnostic Pathology·Edward B Stelow, Hadi Yaziji
Dec 21, 2017·International Journal of Endocrinology·Ting-Ting ZhangQing-Hai Ji

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