A Diallel of the Mouse Collaborative Cross Founders Reveals Strong Strain-Specific Maternal Effects on Litter Size

G3 : Genes - Genomes - Genetics
John R ShorterFernando Pardo-Manuel de Villena


Reproductive success in the eight founder strains of the Collaborative Cross (CC) was measured using a diallel-mating scheme. Over a 48-month period we generated 4,448 litters, and provided 24,782 weaned pups for use in 16 different published experiments. We identified factors that affect the average litter size in a cross by estimating the overall contribution of parent-of-origin, heterosis, inbred, and epistatic effects using a Bayesian zero-truncated overdispersed Poisson mixed model. The phenotypic variance of litter size has a substantial contribution (82%) from unexplained and environmental sources, but no detectable effect of seasonality. Most of the explained variance was due to additive effects (9.2%) and parental sex (maternal vs. paternal strain; 5.8%), with epistasis accounting for 3.4%. Within the parental effects, the effect of the dam's strain explained more than the sire's strain (13.2% vs. 1.8%), and the dam's strain effects account for 74.2% of total variation explained. Dams from strains C57BL/6J and NOD/ShiLtJ increased the expected litter size by a mean of 1.66 and 1.79 pups, whereas dams from strains WSB/EiJ, PWK/PhJ, and CAST/EiJ reduced expected litter size by a mean of 1.51, 0.81, and 0.90 pups. Finally...Continue Reading


Oct 1, 1987·Heredity·T A Mousseau, D A Roff
Apr 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·S J ConwayP S Burgoyne
Dec 1, 1996·Genetical Research·J Zhu, B S Weir
Jan 31, 2003·Nature·Reinmar Hager, Rufus A Johnstone
Nov 1, 1960·Journal of Cellular and Comparative Physiology·D S FALCONER
May 20, 2004·Journal of Evolutionary Biology·A C PeripatoJ M Cheverud
Jan 1, 1956·Genetics·A G Dickinson, J L Jinks
Aug 22, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Elissa J CheslerKenneth F Manly
Oct 7, 2008·BMC Evolutionary Biology·Milos MacholánJaroslav Piálek
Mar 17, 2011·Genome Research·David L AylorGary A Churchill
Mar 24, 2011·American Journal of Physiology. Endocrinology and Metabolism·Wendy Foulds MathesDaniel Pomp
May 24, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Igor KoturbashIgor P Pogribny
Jul 8, 2011·Genome Research·Vivek M PhilipElissa J Chesler
Jan 27, 2012·Evolution; International Journal of Organic Evolution·Leslie M TurnerBettina Harr
Feb 22, 2012·Genetics·UNKNOWN Collaborative Cross Consortium
Feb 22, 2012·Genetics·Alan B LenarcicWilliam Valdar
Mar 3, 2012·G3 : Genes - Genomes - Genetics·Samir N P KeladaFrancis S Collins
Oct 8, 2013·PLoS Genetics·John D CalawayFernando Pardo-Manuel de Villena
Nov 8, 2013·Genes and Immunity·J PhillippiJ A Frelinger
Nov 26, 2013·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Elissa J Chesler
Feb 4, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Allison R RogalaFernando Pardo-Manuel de Villena
Oct 2, 2015·Journal of Anatomy·Christopher J PercivalBenedikt Hallgrímsson
Dec 20, 2015·G3 : Genes - Genomes - Genetics·Andrew P MorganFernando Pardo-Manuel de Villena
Jun 1, 1991·Evolution; International Journal of Organic Evolution·Trevor Price, Dolph Schluter
Jun 9, 2017·Genetics·Anuj SrivastavaFernando Pardo-Manuel de Villena

❮ Previous
Next ❯


Nov 27, 2020·Proceedings of the National Academy of Sciences of the United States of America·Tessa M BertozziAnne C Ferguson-Smith
Aug 10, 2021·Evolution Letters·Karl GrieshopDavid Berger

❮ Previous
Next ❯

Key Resources (RRID) Mentioned


Software Mentioned

R package

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.