A dichotomy in the lipophilicity of natural estrogens, xenoestrogens, and phytoestrogens

Environmental Health Perspectives
A R CunninghamH S Rosenkranz

Abstract

Using two independent analyses, it is demonstrated that natural (e.g., estradiol) and some xenoestrogens (e.g., methoxychlor metabolite) are characterized by a lipophilic region that is absent in nonestrogens as well as in phytoestrogens. It is suggested that this lipophilic region affects binding to specific receptors and may, in fact, differentiate harmful from beneficial estrogens.

References

Dec 1, 1984·Environmental Health Perspectives·L S GoldR Peto
Jan 1, 1996·Archives of Toxicology·A CunninghamH S Rosenkranz

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Citations

Mar 18, 1999·Toxicology and Applied Pharmacology·E Harnagea-TheophilusM R Miller
Oct 6, 1999·Teratology·J GómezH S Rosenkranz
Mar 30, 1999·Current Opinion in Lipidology·A Cassidy
Nov 21, 2000·Statistical Methods in Medical Research·C HelmaS Kramer
Sep 10, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Seong Chul KimMilton H Hamblin
Jan 11, 2005·The American Journal of Clinical Nutrition·Sonia Vega-LópezAlice H Lichtenstein
Mar 20, 1999·The Journal of Nutrition·K D Setchell, A Cassidy

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