A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice

Biochemical and Biophysical Research Communications
Albena T Dinkova-KostovaPaul Talalay

Abstract

Inducible phase 2 enzymes constitute a primary line of cellular defense. The oleanane dicyanotriterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile (TP-225) is a very potent inducer of these systems. Topical application of TP-225 to SKH-1 hairless mice increases the levels of NAD(P)H-quinone acceptor oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO-1) and protects against UV radiation-induced dermal thickening. Daily topical treatments of 10 nmol of TP-225 to the backs of mice that were previously subjected to low-level chronic UVB radiation (30 mJ/cm(2)/session, twice a week for 17 weeks), led to 50% reduction in multiplicity of skin tumors. In addition, the total tumor burden of squamous cell carcinomas was reduced by 5.5-fold. The identification of new agents for protection against UV radiation-induced skin cancer and understanding of their mechanism(s) of action is especially important in view of the fact that human skin cancers represent a significant source of increasing morbidity and mortality.

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H J ProchaskaP Talalay
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P TalalayH J Prochaska
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·A T Dinkova-KostovaP Talalay
Mar 21, 2002·Immunology and Cell Biology·G J ClydesdaleH K Muller
Sep 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yao-Ping LuAllan H Conney
Feb 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nobunao WakabayashiPaul Talalay
Apr 23, 2004·The Journal of Investigative Dermatology·Munif Allanson, Vivienne E Reeve
Nov 3, 2004·Trends in Molecular Medicine·Hozumi Motohashi, Masayuki Yamamoto
Mar 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Albena T Dinkova-KostovaPaul Talalay
Dec 20, 2005·Chemical Research in Toxicology·Albena T Dinkova-KostovaThomas W Kensler
Mar 28, 2006·Journal of Natural Products·Muriel CuendetJohn M Pezzuto
Aug 5, 2006·Advances in Enzyme Regulation·Makoto Kobayashi, Masayuki Yamamoto
Apr 10, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Albena T Dinkova-KostovaPaul Talalay

❮ Previous
Next ❯

Citations

Mar 3, 2011·Archives of Toxicology·Liam Baird, Albena T Dinkova-Kostova
Apr 1, 2010·Pharmaceutical Research·Joydeb Kumar Kundu, Young-Joon Surh
May 8, 2010·Antioxidants & Redox Signaling·John D HayesAlbena T Dinkova-Kostova
May 7, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ian M CoppleB Kevin Park
Oct 1, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yong Pil HwangHye Gwang Jeong
Nov 2, 2017·Archives of Medical Research·Eun Jung ParkKi Churl Chang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.