A diet moderately enriched in phytosterols lowers plasma cholesterol concentrations in normocholesterolemic humans

Annals of Nutrition & Metabolism
X PelletierG Debry

Abstract

Twelve normolipidic healthy human subjects were fed a diet with or without additional soybean phytosterols for 4 weeks in a crossover design. The order of the treatments was randomized. Phytosterols were added to the diet blended in butter. The dietary ratio cholesterol:phytosterols was 0.7 during the control period (436 mg cholesterol/day and 29 mg phytosterols/day) and 1.88 during the phytosterols period (410 mg cholesterol/day and 740 mg phytosterols/day). Blood cholesterol was 10% lower after subjects consumed the phytosterol-enriched diet than when they consumed the control diet (p < 0.001), which was due to a 15% LDL cholesterol decrease (p < 0.001). The HDL cholesterol:LDL cholesterol ratio was markedly enhanced (+25%) (p < 0.01). These findings suggest that a significant lowering of plasma total and LDL cholesterol can be effected by a modest dietary intake of soybean phytosterols.

Citations

Jul 10, 2003·Lipids·Marie-Pierre St-Onge, Peter J H Jones
Dec 21, 2000·Current Atherosclerosis Reports·P J Jones
Dec 19, 2002·Journal of the American Dietetic Association·Arrigo F G CiceroAntonio Gaddi
May 29, 2002·The Journal of Nutritional Biochemistry·C A. VanstoneP J.H. Jones
Mar 11, 2006·Critical Reviews in Food Science and Nutrition·John Flanagan, Harjinder Singh
Apr 9, 2004·Lipids in Health and Disease·Alvin BergerSuhad S Abumweis
Nov 6, 2009·The American Journal of Clinical Nutrition·Susan B RacetteRichard E Ostlund
Sep 28, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A Otaegui-ArrazolaI Astiasarán
Feb 6, 2008·Metabolism: Clinical and Experimental·Amira N KassisPeter J H Jones
Jun 5, 2015·Food Chemistry·Rosa GiacaloneGiovanni Presti
May 6, 2003·Journal of Lipid Research·Peter J H JonesMarie-Pierre St-Onge
Mar 5, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Christos S DerdemezisMoses S Elisaf
May 28, 2004·European Journal of Clinical Nutrition·A B ThomsenA Berger
Feb 26, 2005·Clinical and Experimental Pharmacology & Physiology·O A AdaramoyeG O Emerole
Jan 13, 2006·European Journal of Clinical Nutrition·R KorpelaM J Tikkanen
Mar 18, 2006·Endocrine Journal·Takeshi Usui
Dec 19, 2008·The Journal of Nutrition·Isabelle DemontyElke A Trautwein
Mar 30, 1999·Current Opinion in Lipidology·T A Miettinen, H Gylling
Dec 30, 1998·Current Opinion in Lipidology·I Ikeda, M Sugano
Oct 15, 1998·The Journal of Nutrition·A H Lichtenstein
Nov 27, 2002·The American Journal of Clinical Nutrition·Catherine A VanstonePeter J H Jones
Mar 25, 2000·The American Journal of Clinical Nutrition·L NorménH Andersson
Apr 3, 2001·Nutrition Reviews·P J Jones, M Raeini-Sarjaz
Jul 10, 2018·Current Medicinal Chemistry·Montserrat Cofán, Emilio Ros

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.