A different representation of natural T cells and natural killer cells between tumor-infiltrating and periphery lymphocytes in human hepatocellular carcinoma

Oncology Letters
Xiao-Feng LiWengui Xu

Abstract

Natural T cells [cluster of differentiation (CD) 3(+)CD56(+)] and natural killer (NK) cells (CD3(-)CD56(+)) are particularly abundant in the human liver and serve an important role in immune responses in the liver. The aim of the present study was to extensively determine the phenotypic and functional characteristics of natural T and NK cells in human hepatocellular carcinoma (HCC). Tumorous and non-tumorous tissue infiltrating lymphocytes (TILs and NILs, respectively) and peripheral blood mononuclear cells (PBMCs) from patients with hepatocellular carcinoma (HCC) were obtained to determine the frequency and phenotype of natural T/NK cells by a multicolor fluorescence activated cell sorting analysis. The abundance of natural T cells and NK cells was decreased in TILs vs. NILs (natural T cells, 6.315±1.002 vs. 17.16±1.804; NK cells, 6.324±1.559 vs. 14.52±2.336, respectively). However such results were not observed in PBMCs from HCC patients vs. that of healthy donors. Notably, a substantial fraction of the natural T cells (21.96±5.283) in TILs acquired forkhead box P3 (FOXP3) expression, and the FOXP3(+) natural T cells lost the expression of interferon-γ and perforin. Conversely, being similar to the conventional FOXP3(+) regul...Continue Reading

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Citations

Jun 4, 2019·Frontiers in Immunology·Zenan WangZhaoming Ye
Mar 15, 2018·Frontiers in Immunology·Daniëlle KrijgsmanPeter J K Kuppen
Jan 18, 2021·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Tian-Tian LiXue-Zhang Duan
Sep 30, 2021·Cancer Immunology, Immunotherapy : CII·Markus Bo SchoenbergAlexandr V Bazhin

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