A different TRAP220 expression in distinct histologic subtypes of lung adenocarcinoma and the prognostic significance

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Jeanho YunMee Sook Roh

Abstract

Adenocarcinomas are a very heterogeneous subgroup of lung cancers, in which oncogenesis is linked to different molecular events. Recent evidence suggests that the hormonal status may contribute to the pathogenesis of lung adenocarcinoma. TRAP220 is the main subunit of the TRAP/Mediator complex and it binds to nuclear hormone receptors in the presence of their cognate ligand, as a cofactor of the transcription machinery. Since TRAP220 is an essential coactivator that interacts directly with estrogen receptor β (ERβ), we examined the expression of TRAP220 protein to investigate its role in lung adenocarcinoma, with particular attention being paid to its different histologic subtypes and the ERβ expression. We performed immunohistochemical detection of TRAP220 and ERβ protein in eighty-seven tissue samples from lung adenocarcinoma patients by using a tissue microarray, and Western blotting was then done to confirm the immunohistochemical observations. TRAP220 immunoreactivity was observed in 27 (31.0%) of the 87 adenocarcinoma cases. Analysis of the TRAP220 expression by Western blotting confirmed the immunohistochemical results. The TRAP220 expression was more frequently positive in the non-solid subtypes (bronchioloalveolar, aci...Continue Reading

References

Apr 26, 2003·International Journal of Epidemiology·Michaela KreuzerH-Erich Wichmann
May 18, 2005·Trends in Biochemical Sciences·Roger D Kornberg
May 18, 2005·Trends in Biochemical Sciences·Sohail Malik, Robert G Roeder
Mar 14, 2007·Annals of Diagnostic Pathology·Mary WahbahMahmoud Eltorky
Feb 27, 2009·International Journal of Cancer. Journal International Du Cancer·Jean de La Croix NdongRaymond Frade
Jun 13, 2009·International Journal of Cancer. Journal International Du Cancer·Padmaja GadeDhananjaya V Kalvakolanu
Jul 9, 2009·Chest·Frank C DetterbeckLynn T Tanoue

❮ Previous
Next ❯

Citations

Feb 11, 2011·Journal of Experimental & Clinical Cancer Research : CR·Liangan ChenYanqin Li
Jun 7, 2012·Annals of Surgical Oncology·Teruhisa TakuwaAtsushi Ochiai
Jul 2, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyung A KwonHyo-Jin Kim
Aug 16, 2011·Seminars in Cell & Developmental Biology·Jason M SpaethThomas G Boyer
Oct 11, 2011·Biochimie·Claudio NapoliAmelia Casamassimi
Jul 10, 2013·Korean Journal of Pathology·Sangjeong AhnChul Hwan Kim
Apr 22, 2017·Acta Biochimica Et Biophysica Sinica·Hyun-Ju Kim, Jeanho Yun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.