PMID: 6979027Jan 1, 1982Paper

A differentiation antigen expressed selectively by a proportion of human blood cells: detection with a monoclonal antibody

Pathology
D A BrooksH Zola

Abstract

A monoclonal antibody, FMC 8, has been prepared after immunization with a cell line of the non-T-non-B type acute lymphoblastic leukaemia (ALL). The antigen detected by this antibody consists of a single polypeptide chain with an apparent molecular weight of 24,000 d. The antigen is absent from T cells but appears after mitogen stimulation. It is found on the majority of normal circulating B cells but is absent in most chronic lymphocytic leukaemias. All cells of the non-T-non-B type express the antigen, whereas T-ALL cells generally do not. Granulocytes, monocytes and platelets react with the antibody, but erythrocytes do not. The wide but selective distribution of the antigen renders FMC 8 potentially useful, together with other monoclonal antibodies, in the delineation of differentiation pathways and in phenotypic analysis of leukaemia and lymphoma cells.

References

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Citations

Feb 11, 1985·Journal of Immunological Methods·H ZolaJ Bradley
Sep 1, 1983·Journal of Reproductive Immunology·H ZolaP C Beverley
Jul 1, 1988·The Journal of Experimental Medicine·D N Hart, J L McKenzie
Jun 1, 1984·Journal of Clinical Pathology·J Tavares de CastroD Catovsky
Jan 1, 1986·Journal of Clinical Pathology·D M SalterA E Dewar
May 7, 2016·The Hastings Center Report·Joseph A Stramondo
Jan 1, 1983·Immunology Today·I F McKenzie, H Zola
Jan 1, 1985·Leukemia Research·R SeshadriA A Morley
Apr 15, 1985·International Journal of Cancer. Journal International Du Cancer·M RoweM A Epstein
Jul 1, 1986·Hematological Oncology·D N HartM Southern
Mar 1, 1988·The Journal of Pathology·D M SalterS Cunningham
Jan 1, 1986·British Journal of Haematology·J F San MiguelA Lopez Borrasca
Nov 1, 1986·British Journal of Haematology·J F San MiguelA Lopez Borrasca
Feb 22, 2012·Expert Opinion on Biological Therapy·Juan Javier ServatJohn J Huang
Jul 1, 1986·Scandinavian Journal of Haematology·J F San MiguelD Catovsky

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