PMID: 3772740Aug 1, 1986Paper

A diffusion-diffusion model for percutaneous drug absorption

Journal of Pharmacokinetics and Biopharmaceutics
K Kubota, T Ishizaki

Abstract

Several theories describing percutaneous drug absorption have been proposed, incorporating the mathematical solutions of differential equations describing percutaneous drug absorption processes where the vehicle and skin are regarded as simple diffusion membranes. By a solution derived from Laplace transforms, the mean residence time MRT and the variance of the residence time VRT in the vehicle are expressed as simple elementary functions of the following five pharmacokinetic parameters characterizing the percutaneous drug absorption: kd, which is defined as the normalized diffusion coefficient of the skin, kc, which is defined as the normalized skin-capillary boundary clearance, the apparent length of diffusion of the skin 1d, the effective length of the vehicle lv, and the diffusion coefficient of the vehicle Dv. All five parameters can be obtained by the methods proposed here. Results of numerical computation indicate that: concentration-distance curves in the vehicle and skin approximate two curves which are simply expressed using trigonometric functions when sufficient time elapses after an ointment application; the most suitable condition for the assumption that the concentration of a drug in the uppermost epidermis can b...Continue Reading

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Citations

Jan 1, 1992·European Journal of Clinical Pharmacology·M Weiss
Apr 1, 1991·Computers and Biomedical Research, an International Journal·K Kubota
Feb 11, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M Schalla, M Weiss
Jul 29, 2009·The Annals of Occupational Hygiene·Kenneth W FentLeena A Nylander-French
Jan 1, 1990·Drug Metabolism Reviews·J Kao, M P Carver
Jun 1, 1999·Drug Development and Industrial Pharmacy·G J RheeC H Lee
Dec 29, 2005·Journal of Pharmaceutical Sciences·Gerald B Kasting, Matthew A Miller

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