A diffusion tensor imaging and neurocognitive study of HIV-positive children who are HAART-naïve "slow progressors".

Journal of Neurovirology
Jacqueline HoareDan Stein

Abstract

There are few neuropsychological or neuroimaging studies of HIV-positive children with "slow progression". "Slow progressors" are typically defined as children or adolescents who were vertically infected with HIV, but who received no or minimal antiretroviral therapy. We compared 12 asymptomatic HIV-positive children (8 to 12 years) with matched controls on a neuropsychological battery as well as diffusion tensor imaging in a masked region of interest analysis focusing on the corpus callosum, internal capsule and superior longitudinal fasciculus. The "slow progressor" group performed significantly worse than controls on the Wechsler Abbreviated Scale of Intelligence Verbal and Performance IQ scales, and on standardised tests of visuospatial processing, visual memory and executive functioning. "Slow progressors" had lower fractional anisotropy (FA), higher mean diffusivity (MD) and radial diffusivity (RD) in the corpus callosum (p= <0.05), and increased MD in the superior longitudinal fasciculus, compared to controls. A correlation was found between poor performance on a test of executive function and a test of attention with corpus callosum FA, and a test of executive function with lowered FA in the superior longitudinal fasicu...Continue Reading

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Citations

Jun 21, 2013·Journal of the International AIDS Society·Barbara LaughtonAnnelies Van Rie
Dec 17, 2014·New Directions for Child and Adolescent Development·Amina Abubakar
Jan 20, 2015·AIDS Research and Therapy·Kirsten A DonaldJo M Wilmshurst
Nov 30, 2014·Indian Journal of Pediatrics·Manisha GhateDileep Kadam
Jan 22, 2015·Journal of Neurovirology·Jacqueline HoareDan J Stein
Feb 23, 2017·NeuroImage. Clinical·Santosh K YadavMohammad Haris
Mar 24, 2017·Journal of Tropical Pediatrics·Kenechukwu K IlohAdaeze C Ayuk
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Jan 6, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Robert PaulStephen Kerr
Jun 20, 2015·The Pediatric Infectious Disease Journal·Neda JahanshadUNKNOWN SEARCH 012 and the PREDICT Study Groups
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May 11, 2020·Current HIV/AIDS Reports·Veronica Obregon-PerkoAnn Chahroudi
Dec 4, 2016·Journal of Neurovirology·Robert H PaulJohn Joska

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